Jörg Stülke

TL;DR: Together, these data suggest that wild-type aconitase binds to and destabilizes the citZ transcript in order to maintain proper cell homeostasis by preventing the overaccumulation of citrate.

TL;DR: This study shows that although B. subtilis ATCC 6633 and 168 are able to produce various processed lantibiotic peptides, an evident advantage of using either the 8-fold protease-deficient strain WB800 or the genome-minimized B. subilis 168 strain PG10 is the lack of extracellular serine protease activity, which means potential toxicity toward the production host is prevented.

TL;DR: SPABBATS is the first application of SAT techniques to metabolic problems, particularly useful for the characterization of metabolic suppressor mutants and can be used in a synthetic biology setting to design new pathways with specific input-output requirements.

TL;DR: The formation of doubly phosphorylated HPr is substantially slower as compared to the phosphorylation of free HPr, but the rate of formation is sufficient to account for the amount of HPr(His approximately P)(Ser-P) detected in M. pneumoniae cells.

TL;DR: In this paper, it was shown that the essentiality of c-di-AMP in Bacillus subtilis is caused by the global impact of the second messenger nucleotide on different aspects of cellular physiology.