S
Stefan Tholen
Researcher at University of Freiburg
Publications - 30
Citations - 903
Stefan Tholen is an academic researcher from University of Freiburg. The author has contributed to research in topics: Cathepsin B & Medicine. The author has an hindex of 15, co-authored 25 publications receiving 574 citations. Previous affiliations of Stefan Tholen include Stanford University & University of Göttingen.
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Understanding fibroblast activation protein (FAP): Substrates, activities, expression and targeting for cancer therapy
TL;DR: The need to better define the substrate repertoire and expression patterns of FAP to elucidate its role in biological and pathological processes is highlighted, emphasising the need for methods to exploit and target this protease more rapidly.
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Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease
Daniel Erny,Nikolaos Dokalis,Charlotte Mezö,Angela Castoldi,Omar Mossad,Ori Staszewski,Maximilian Frosch,Matteo Villa,Vidmante Fuchs,Arun Mayer,Jana Neuber,Janika Sosat,Stefan Tholen,Oliver Schilling,Andreas Vlachos,Thomas Blank,Mercedes Gomez de Agüero,Andrew J. Macpherson,Edward J. Pearce,Edward J. Pearce,Marco Prinz +20 more
TL;DR: This paper found that the immature phenotype of microglia from germ-free (GF) mice is epigenetically imprinted by H3K4me3 and H3k9ac on metabolic genes associated with substantial functional alterations including increased mitochondrial mass and specific respiratory chain dysfunctions.
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Fibroblast activation protein-α, a stromal cell surface protease, shapes key features of cancer associated fibroblasts through proteome and degradome alterations.
Maria Magdalena Koczorowska,Stefan Tholen,Felicitas Bucher,Lisa Lutz,Jayachandran N. Kizhakkedathu,O. De Wever,Ulrich F. Wellner,Martin L. Biniossek,Andreas Stahl,Silke Lassmann,Silke Lassmann,Silke Lassmann,Oliver Schilling,Oliver Schilling +13 more
TL;DR: The findings link FAP α to key aspects of CAF biology and attribute an important role in tumor–stroma interaction to FAPα.
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A Transcriptional Circuit Filters Oscillating Circadian Hormonal Inputs to Regulate Fat Cell Differentiation.
Zahra Bahrami-Nejad,Minglei Zhao,Stefan Tholen,Devon M. Hunerdosse,Karen E. Tkach,Sabine N. S. van Schie,Mingyu Chung,Mary N. Teruel +7 more
TL;DR: The mechanism of how hormone oscillations are filtered as a combination of slow and fast positive feedback centered on PPARG is identified, providing a molecular mechanism for why stress, Cushing's disease, and other conditions for which glucocorticoid secretion loses its pulsatility may lead to obesity.
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A High-Frequency Mutation in Bacillus subtilis: Requirements for the Decryptification of the gudB Glutamate Dehydrogenase Gene
TL;DR: In this paper, the authors found that the transcription-repair coupling factor Mfd is required for the decryption of Bacillus subtilis decoders, which is a built-in precaution that facilitates the accumulation of mutations preferentially in transcribed genes.