Showing papers in "Seminars in Arthritis and Rheumatism in 2009"

TL;DR: PVO is an illness of middle-aged individuals with underlying medical illnesses, although the mortality rate is low, relapses and neurological deficits are common, making early diagnosis a major challenge for the physician.

TL;DR: Assessment, after review of 1512 publications, is that oral colchicine therapy is being refined by attention to novel targets such as NALP3 and pyrin, and potentially serious drug-drug interactions are better recognized and therefore preventable.

TL;DR: The results from the present study support the use of carotid ultrasonography as a predictor of CV events in RA.

TL;DR: The improvement in the lipoprotein profile in RA appears to be associated with suppression of inflammation, and lipid levels should be monitored and managed in patients with RA to minimize the long-term risk of cardiovascular disease.

TL;DR: The 3 proposed subsets of OA display distinct etiological, clinical, and therapeutic characteristics and should therefore no longer be considered to be "Primary OA."

TL;DR: Multimorbidity is frequent in the general population and can considerably impair daily functioning and HRQoL and having a rheumatic disease worsens these outcomes.

TL;DR: Interleukin-6 appears to be the central mediator of anemia of chronic disease in a range of inflammatory diseases, including end-stage renal disease and rheumatoid arthritis, through increased generation of hepcidin and the resultant alterations in iron metabolism.

TL;DR: The study showed that during the summer season, vitamin D insufficiency is very common in healthy adult Moroccan women and Lack of sun exposure and veiled clothing style were the most important factors that influenced hypovitaminosis D.

TL;DR: Children with Churg-Strauss syndrome had a predominance of cardiopulmonary disease manifestations, a lower rate of peripheral nerve involvement, and higher mortality, as compared with adult CSS patients.

TL;DR: A systematic review of the literature examining adherence with treatments for inflammatory rheumatic conditions suggests that nonadherence is a substantial problem in this patient population.

TL;DR: IA-BioHA therapy resulted in significant OA knee pain relief at 26 weeks compared with IA-SA and also experienced significant improvements in joint function, treatment satisfaction, and HRQoL.

TL;DR: While prolonged, very low levels of IgG and/or IgM are associated with a heightened risk of infections, transient or less severe immunodeficiency appears to be tolerated in most subjects.

TL;DR: Over a 3-month treatment period, topical treatment with DSG achieved statistically and clinically significant improvements of pain and measures of physical function in patients with knee osteoarthritis.

TL;DR: Patients with diffuse idiopathic skeletal hyperostosis have a significantly higher likelihood to be affected by metabolic syndrome than non-DISH patients and have a substantially higher 10-year CHD risk.

TL;DR: One of the cases represents the first report of the association of HOA with lung transplantation and involvement of vascular endothelial growth factor, platelet-derived growth factor and platelets in the pathogenesis has been postulated and supported by recent data.

TL;DR: PTX3 is physiologically a protective molecule, however, in several autoimmune diseases PTX3 appears to facilitate the development of autoimmunity.

TL;DR: This study shows that NVC can be useful in quantitatively and reproducibly recording various parameters and suggests that combining the parameters showing the greatest reliability and prognostic value may be the best means of analyzing NVC images.

TL;DR: Rituximab is an important addition to the rheumatologist's armamentarium for the treatment of difficult RA and ongoing trials will determine its utility in other indications for RA and other autoimmune conditions.

TL;DR: Pleuritic inflammation and pain may have an important role in the pathogenesis of SLS and a possible mechanism linking pleural inflammation and diaphragm dysfunction may be via a reflex inhibition ofdiaphragmatic activation.

TL;DR: Liposome's application to arthritis is still in its infancy but appears promising as new patents are filed, and recent research into synovial targets and improved liposomal formulations continues to improve the capacity to use liposomes for targeted delivery.

TL;DR: The adiponectin adipokine axis might play a role in RA because of the high levels of expression in the peripheral blood mononuclear cells and in the synovial compartment of rheumatoid arthritis patients.

TL;DR: A concise appraisal of recent studies investigating the involvement of inflammatory cytokines in the pathogenesis of nonarticular RA manifestations is provided to allow clinicians to select therapies to better match the spectrum of joint disease andNonarticular manifestations in individual patients.

TL;DR: In PsA patients without clinically evident CV disease there is a correlation between serum uric acid concentration and subclinical atherosclerosis.

TL;DR: Densitometrists and clinicians should expect that at least 4 of every 10 patients tested by DXA to demonstrate T-score discordance between spine and total hip measurement sites, and age, menopause, and obesity were identified as risk factors against T- score discordance.

TL;DR: In general, anti-TNFalpha therapy has a beneficial effect on bone density and bone turnover markers.

TL;DR: A systematic approach to the classification and diagnosis of work-related UE conditions is attractive, as it is likely to lead to more precise estimates of the prevalence and cost of UE conditions, as well as improved quality of information on the efficacy of medical and workplace interventions.

TL;DR: Treatment with infliximab plus MTX significantly improved hemoglobin level among anemic RA patients when compared with treatment with placebo plusMTX, even after adjusting for improvement in disease activity.

TL;DR: The reactivation or the unmasking of gastrointestinal symptoms during etanercept treatment raises the issue of differences between etanenercept and the other antitumor necrosis factor monoclonal antibodies in their molecular structure, tumor necrosis factors neutralizing effect, mode of administration, and pharmacokinetics that may account for these observations.

TL;DR: Axi, a marker of arterial stiffness, as well as IMT, a markers of large-artery remodeling, are increased in RA patients without traditional cardiovascular risk factors.