Jorge H Fernandez

TL;DR: Peptide-like BPP structures, naturally developed by snakes across millions of years of evolution, appear to be good candidates for the development of domain-selective ACE inhibitors with high stability and improved pharmacological profiles.

TL;DR: The results suggest that bothrostatin adopts a globular, closed structure in solution, and the proximity of the RGD loop and the C-terminal residues are involved in the ability of both frostatin to interact with its ligands.

TL;DR: Results suggest that GST27.2 may play an important part in plant defenses against Al toxicity, and phylogenetic analysis of theta-type GSTs revealed that the gene belongs to a group of proteins that respond to different stresses.

TL;DR: The molecular modeling of the N-terminal human somatic ACE in complex with the inhibitor lisinopril is described, identifying the residues involved in the inhibitor-binding pocket and an important carboxy- terminating proline hydrophobic accommodations mediated by the aromatic ring of Tyr532 and Tyr1128 residues.

TL;DR: To further understanding the regulatory network in response to stress, the yeast two-hybrid system was used to identify sugarcane proteins that interact with SsNAC23, a member of the NAC family of plant-specific transcription factors, which are induced by low temperature and other stresses in several plant species.