J
Jorge H. Medina
Researcher at University of Buenos Aires
Publications - 298
Citations - 21591
Jorge H. Medina is an academic researcher from University of Buenos Aires. The author has contributed to research in topics: Hippocampus & Memory consolidation. The author has an hindex of 76, co-authored 291 publications receiving 20422 citations. Previous affiliations of Jorge H. Medina include Pontifícia Universidade Católica do Rio Grande do Sul & Universidade Federal do Rio Grande do Sul.
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Journal ArticleDOI
Memory formation: the sequence of biochemical events in the hippocampus and its connection to activity in other brain structures.
Ivan Izquierdo,Jorge H. Medina +1 more
TL;DR: It is suggested that the hippocampal chain of events that underlies memory formation is linked to long-term storage elsewhere through activity-dependent changes in cell connectivity.
Journal ArticleDOI
BDNF is essential to promote persistence of long-term memory storage.
Pedro Bekinschtein,Martín Cammarota,Cynthia Katche,Leandro Slipczuk,Janine I. Rossato,Andrea Paula Goldin,Ivan Izquierdo,Jorge H. Medina +7 more
TL;DR: It is demonstrated that intrahippocampal delivery of BDNF reverses the deficit in memory persistence caused by inhibition of hippocampal protein synthesis, and induces memory persistence by itself, transforming a nonlasting LTM trace into a persistent one in an ERK-dependent manner.
Journal ArticleDOI
Persistence of Long-Term Memory Storage Requires a Late Protein Synthesis- and BDNF- Dependent Phase in the Hippocampus
Pedro Bekinschtein,Martín Cammarota,Lionel M. Igaz,Lia R. M. Bevilaqua,Ivan Izquierdo,Jorge H. Medina +5 more
TL;DR: It is shown that 12 hr after acquisition of a one-trial associative learning task, there is a novel protein synthesis and BDNF-dependent phase in the rat hippocampus that is critical for the persistence of LTM storage.
Journal ArticleDOI
Involvement of hippocampal cAMP/cAMP-dependent protein kinase signaling pathways in a late memory consolidation phase of aversively motivated learning in rats
Ramon Bernabeu,Lia R. M. Bevilaqua,Patrícia Ardenghi,Elke Bromberg,P. K. Schmitz,Marino Muxfeldt Bianchin,Ivan Izquierdo,Jorge H. Medina +7 more
TL;DR: It is reported that a late memory consolidation phase of an inhibitory avoidance learning is regulated by an hippocampal cAMP signaling pathway that is activated, at least in part, by D1/D5 receptors.
Journal ArticleDOI
Different molecular cascades in different sites of the brain control memory consolidation
Ivan Izquierdo,Lia R. M. Bevilaqua,Lia R. M. Bevilaqua,Janine I. Rossato,Janine I. Rossato,Juliana Sartori Bonini,Juliana Sartori Bonini,Jorge H. Medina,Jorge H. Medina,Martín Cammarota,Martín Cammarota +10 more
TL;DR: Memory consolidation involves a complex network of brain systems and serial and parallel molecular events, even for a task as deceptively simple as one-trial avoidance, and is proposed that these molecular events might also be involved in many other memory types in animals and humans.