J
Jørgen Wesche
Researcher at University of Oslo
Publications - 50
Citations - 2994
Jørgen Wesche is an academic researcher from University of Oslo. The author has contributed to research in topics: Fibroblast growth factor receptor & Cytosol. The author has an hindex of 24, co-authored 48 publications receiving 2705 citations. Previous affiliations of Jørgen Wesche include Harvard University & Akershus University Hospital.
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Journal ArticleDOI
Fibroblast growth factors and their receptors in cancer.
TL;DR: An overview of FGF signalling, the main FGFR alterations found in human cancer to date, how they may contribute to specific cancer types and strategies for therapeutic intervention are given.
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Roles of Fibroblast Growth Factor Receptors in Carcinogenesis
TL;DR: An overview of the main FGFR alterations described in human cancer to date is given and their contribution to cancer progression is discussed.
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Ubiquitination of α5β1 Integrin Controls Fibroblast Migration through Lysosomal Degradation of Fibronectin-Integrin Complexes
Viola Hélène Lobert,Andreas Brech,Andreas Brech,Nina Pedersen,Nina Pedersen,Jørgen Wesche,Jørgen Wesche,Angela Oppelt,Angela Oppelt,Lene Malerød,Lene Malerød,Harald Stenmark +11 more
TL;DR: It is demonstrated that in migrating cells, a fraction of the endocytosed fibronectin receptor, alpha 5 beta 1 integrin, is sorted into multivesicular endosomes together with fibronECTin and degraded in lysosomes.
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Dependence of ricin toxicity on translocation of the toxin A-chain from the endoplasmic reticulum to the cytosol.
TL;DR: In this paper, retrograde intracellular transport and translocation of ricin was studied under conditions that alter the sensitivity of cells to the toxin, and the results indicated that retrograde translocation across the ER membrane is required for intoxication.
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Characterization of Membrane Translocation by Anthrax Protective Antigen
TL;DR: An assay for translocation in which radiolabeled ligands are bound to proteolytically activated PA at the surface of CHO or L6 cells, and translocation across the plasma membrane is induced by lowering the pH demonstrates that the acid-induced translocation by anthrax toxin closely resembles that of diphtheria toxin, despite the fact that these two toxins are unrelated and form pores by different mechanisms.