Showing papers in "Developmental Cell in 2010"

TL;DR: Recent studies suggest that the core Hippo kinase cascade integrates multiple upstream inputs, enabling dynamic regulation of tissue homeostasis in animal development and physiology.

TL;DR: Understanding the complex ways in which cancer cells interact with their surroundings, both locally in the tumor organ and systemically in the body as a whole, has implications for effective cancer prevention and therapy.

TL;DR: It is proposed that NRT1.1 represses lateral root growth at low nitrate availability by promoting basipetal auxin transport out of these roots, which defines a mechanism connecting nutrient and hormone signaling during organ development.

TL;DR: Many gaps remain in knowledge, the filling of which is essential for understanding respiratory disorders, congenital defects in human neonates, and how the disruption of morphogenetic programs early in lung development can lead to deficiencies that persist throughout life.

TL;DR: It is shown that in the morula, blastomeres coexpress transcription factors specific to different lineages, but by the 64-cell stage three cell types can be clearly distinguished according to their quantitative expression profiles.

TL;DR: Findings reveal the specific involvement of immature osteoblast precursors in the coupled vascular and osteogenic transformation essential to endochondral bone development and repair.

TL;DR: This work uses transcript profiling and chromatin-immunoprecipitation microarray experiments to identify 953 BR-regulated BZR1 target (BRBT) genes and reveals a regulatory network that integrates hormonal and light-signaling pathways for plant growth regulation.

TL;DR: It is demonstrated that different levels of CyclinB1-Cdk1 kinase activity trigger different mitotic events, thus revealing how the remarkable reorganization of the cell is coordinated at mitotic entry.

TL;DR: It is demonstrated that the Merlin/NF2 tumor suppressor and the YAP oncoprotein function antagonistically to regulate liver development and implicate YAP activation as a mediator of pathologies relevant to Neurofibromatosis 2.

TL;DR: The basic molecular mechanisms that control the formation of the liver as an organ are reviewed.

TL;DR: It is demonstrated that TAZ/YAP dictate the localization of active SMAD complexes in response to cell density-mediated formation of polarity complexes, and that disruption of the Crumbs complex enhances TGF-β signaling and predisposes cells to T GF-β-mediated epithelial-to-mesenchymal transitions.

TL;DR: The results reveal one means by which GAs suppress cellular competence to respond to JA, and suggest a candidate mechanism by which JA signaling may be fine-tuned by other signaling pathways through DELLAs.

TL;DR: The two major components of the kidney, the collecting system and the nephron, have different developmental histories, and their embryological origin and the genes controlling their morphogenesis, patterning, and differentiation are considered.

TL;DR: An overview of how epigenetic factors, including genomic DNA methylation, histone modifications, and microRNA regulation, contribute to normal development, paying special attention to their role in regulating tissue-specific genes, is provided.

TL;DR: It is shown that the Hippo pathway restricts Wnt/beta-Catenin signaling by promoting an interaction between TAZ and DVL in the cytoplasm, and this work highlights the role of the hippo pathway in coordinating morphogenetic signaling with growth control.

TL;DR: A role for N-cadherin during contact inhibition of locomotion is shown and a mechanism of chemoattraction likely to function during both embryogenesis and cancer metastasis is revealed, whereby attractants such as Sdf1 amplify and stabilize contact-dependent cell polarity, resulting in directional collective migration.

TL;DR: It is shown that Kibra functions together with Mer and Ex in a protein complex localized to the apical domain of epithelial cells, and that this protein complex regulates the Hippo kinase cascade via direct binding to Hpo and Sav.

TL;DR: The roles of miRNAs as regulators of cardiac form and function, unresolved questions in the field, and issues for the future are discussed.

TL;DR: It is demonstrated thatcallus resembles the tip of a root meristem, even if it is derived from aerial organs such as petals, which clearly shows that callus formation is not a simple reprogramming process backward to an undifferentiated state as widely believed.

TL;DR: Findings were that MyoD was constitutively bound to thousands of additional sites in both myoblasts and myotubes, and that the genome-wide binding of Myo D was associated with regional histone acetylation.

TL;DR: It is suggested that Kibra is part of an apical scaffold that promotes SWH pathway activity and is conserved in human cells.

TL;DR: This work focuses on rigidity sensing mediated through the integrin family of extracellular matrix receptors and linked proteins and discusses the evidence supporting these proteins as mechanosensors.

TL;DR: This work uses in vivo biotin labeling of a nuclear envelope protein in individual cell types followed by affinity isolation of labeled nuclei to measure gene expression and chromatin features of the hair and non-hair cell types of the Arabidopsis root epidermis.

TL;DR: It is found that plant-derived cytokinins promote resistance of Arabidopsis to Pseudomonas syringae pv to tomato DC3000 (Pst), and cytokinin-activated transcription factor ARR2 contributes specifically to Pst resistance.

TL;DR: It is shown that a matrix protein hnRNP U/SP120/SAF-A is required for the accumulation of Xist RNA on the Xi and proposed that the association with matrix proteins is an essential step in the epigenetic regulation of gene expression by XistRNA.

TL;DR: It is shown that phosphoinositide 3-kinase mediates neutrophil migration in vivo by differentially regulating cell protrusion and polarity, and this work provides new insight into how cell signaling at the front and back of the cell is coordinated during polarized cell migration in intact tissues within a multicellular organism.

TL;DR: A signaling loop that employs Wnt/beta-catenin signaling in both epithelial progenitor cells and their mesenchymal niche to govern and coordinate the interactions between these compartments to guide hair morphogenesis is revealed.

TL;DR: Kibra predominantly acts in the Merlin branch upstream of the core kinase cascade to regulate Hippo signaling, and acts synergistically with Expanded, and it physically interacts with Merlin.

TL;DR: Under stress conditions, FoxO inhibits the anabolic activity of mTORC1, a major consumer of cellular energy, while activating Akt, which increases cellular energy metabolism, thereby maintaining cellular energy homeostasis.

TL;DR: The role of the Doublesex-related transcription factor DMRT1 is examined in adult spermatogenesis using conditional gene targeting in the mouse to find out how it allows abundant, continuous production of sperm.