J
José M. Honrubia
Researcher at Spanish National Research Council
Publications - 9
Citations - 317
José M. Honrubia is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Coronavirus & Viral replication. The author has an hindex of 3, co-authored 6 publications receiving 185 citations.
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Journal ArticleDOI
Role of severe acute respiratory syndrome coronavirus viroporins E, 3a, and 8a in replication and pathogenesis
Carlos Castaño-Rodríguez,José M. Honrubia,Javier Gutiérrez-Álvarez,Marta L. DeDiego,Jose L. Nieto-Torres,Jose M. Jimenez-Guardeño,Jose Angel Regla-Nava,Raúl Fernandez-Delgado,Carmina Verdiá-Báguena,María Queralt-Martín,Grazyna Kochan,Stanley Perlman,Vicente M. Aguilella,Isabel Sola,Luis Enjuanes +14 more
TL;DR: Key roles for the ion channel and PBM domains in optimal virus replication and pathogenesis are demonstrated and suggest that the viral viroporins and PBMs are suitable targets for antiviral therapy and for mutation in attenuated SARS-CoV vaccines.
Journal ArticleDOI
Cross-neutralization activity against SARS-CoV-2 is present in currently available intravenous immunoglobulins.
José M. Diez,Carolina Romero,Júlia Vergara-Alert,Melissa Bello-Perez,Jordi Rodon,José M. Honrubia,Joaquim Segalés,Isabel Sola,Luis Enjuanes,Rodrigo Gajardo +9 more
TL;DR: The tested IVIG contain antibodies with significant in vitro cross-neutralization capacity against SARS-CoV-2 and SARS -CoV, but not MERS-Cov, which are currently under evaluation as potential therapies for COVID-19.
Posted ContentDOI
Cross-neutralization activity against SARS-CoV-2 is present in currently available intravenous immunoglobulins
José M. Diez,Carolina Romero,Júlia Vergara-Alert,Melissa Bello-Perez,Jordi Rodon,José M. Honrubia,Joaquim Segalés,Isabel Sola,Luis Enjuanes,Rodrigo Gajardo +9 more
TL;DR: In cell culture neutralization assays, the tested IVIG products contain antibodies with significant cross-neutralization capacity against SARS-CoV-2 and SARS -CoV, however, no neutralization capacity was demonstrated against MERS-coV.
Journal ArticleDOI
Genetically Engineered Live-Attenuated Middle East Respiratory Syndrome Coronavirus Viruses Confer Full Protection against Lethal Infection.
Javier Gutiérrez-Álvarez,José M. Honrubia,Raúl Fernandez-Delgado,Li Wang,Carlos Castaño-Rodríguez,Sonia Zuñiga,Isabel Sola,Luis Enjuanes +7 more
TL;DR: In this paper, a collection of mutants carrying partial deletions spanning the C-terminal domain of the E protein (rMERS-CoV-E*) has been generated using a reverse genetics system.
Journal ArticleDOI
Middle East respiratory syndrome coronavirus vaccine based on a propagation-defective RNA replicon elicited sterilizing immunity in mice.
Javier Gutiérrez-Álvarez,José M. Honrubia,A Sanz-Bravo,E González-Miranda,Raúl Fernandez-Delgado,M T Rejas,Sonia Zuñiga,Isabel Sola,Luis Enjuanes +8 more
TL;DR: In this paper, the deletion of the envelope (E) gene from the Middle East respiratory syndrome coronavirus (MERS-CoV) produces a replication-competent propagation-defective RNA replicon.