EASL-EORTC clinical practice guidelines : management of hepatocellular carcinoma

Since the publication of the American Association for the Study of Liver Diseases (AASLD) practice guidelines on the management of hepatocellular carcinoma (HCC) in 2005, new information has emerged that requires that the guidelines be updated. The full version of the new guidelines is available on the AASLD Web site at http://www.aasld.org/practiceguidelines/ Documents/Bookmarked%20Practice%20Guidelines/ HCCUpdate2010.pdf. Here, we briefly describe only new or changed recommendations.

/pdf/aasld-practice-guideline-management-of-hepatocellular-51bocalv0r.pdf

AASLD PRACTICE GUIDELINE Management of Hepatocellular Carcinoma: An Update

https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/hep.20933

Management of hepatocellular carcinoma.

https://aasldpubs.onlinelibrary.wiley.com/doi/pdf/10.1002/hep.22759

Diagnosis, management, and treatment of hepatitis C: An update

EASL–EORTC Clinical Practice Guidelines (CPG) on the management of hepatocellular carcinoma (HCC) define the use of surveillance, diagnosis, and therapeutic strategies recommended for patients with this type of cancer. This is the first European joint effort by the European Association for the Study of the Liver (EASL) and the European Organization for Research and Treatment of Cancer (EORTC) to provide common guidelines for the management of hepatocellular carcinoma. These guidelines update the recommendations reported by the EASL panel of experts in HCC published in 2001 [1]. Several clinical and scientific advances have occurred during the past decade and, thus, a modern version of the document is urgently needed. The purpose of this document is to assist physicians, patients, health-care providers, and health-policy makers from Europe and worldwide in the decision-making process according to evidencebased data. Users of these guidelines should be aware that the recommendations are intended to guide clinical practice in circumstances where all possible resources and therapies are available. Thus, they should adapt the recommendations to their local regulations and/or team capacities, infrastructure, and cost– benefit strategies. Finally, this document sets out some recommendations that should be instrumental in advancing the research and knowledge of this disease and ultimately contribute to improve patient care. The EASL–EORTC CPG on the management of hepatocellular carcinoma provide recommendations based on the level of evidence and the strength of the data (the classification of evidence is adapted from National Cancer Institute [2]) (Table 1A) and the strength of recommendations following previously reported systems (GRADE systems) (Table 1B).

http://www.bclc.cat/download/easl-guidelines.pdf

EASL-EORTC Clinical Practice Guidelines: Management of hepatocellular carcinoma European Association for the Study of the Liver ⇑ , European Organisation for Research and Treatment of Cancer

Composite laminates subjected to out-of-plane loads develop damage modes that compromise the load-carrying capacity, as in the fuselage skin of an aircraft. Therefore, we aimed to improve the damage resistance and tolerance of carbon/epoxy thin non-crimp fabric (NCF) laminates by (a) reducing the &lsquo;conventional&rsquo; ply-thickness (i.e. comparing thick- and thin-plies) (b) interleaving co-polyamide (CoPA) non-woven veils at the interlaminar regions of thin-ply systems. We devised an impact, compression after impact (CAI) and quasi-static indentation (QSI) experimental campaign, where computerized X-ray tomography provided detailed 3D insight on how matrix cracking, delamination and fibre failure interacted during impact and QSI. Thin-ply laminates reduce the amount of matrix cracking and delamination at the cost of premature fibre breakage, therefore decreasing the damage tolerance. Interleaving CoPA veils arrests delamination onset and improves the residual strength with respect to the thin-ply baseline. &nbsp; [1] S.Sihn, R.Y. Kim, K.Kawabe and S.W. Tsai, Compos. Sci. Technol., vol. 67, no. 6, pp. 996&ndash;1008 (2007). https://doi.org/10.1016/j.compscitech.2006.06.008[2] V.A.Ramirez, P.J.Hogg and W.W.Sampson, Compos. Sci. Technol., vol. 110, pp. 103&ndash;110 (2015). https://doi.org/10.1016/j.compscitech.2015.01.016 

Effect of ply-thickness on the impact response of interleaved thin-ply non-crimp-fabric laminates: X-ray tomography investigation

Early HCV viral kinetics after liver transplantation

Thin films of highly transparent amorphous silicon oxynitride (a-SiOxNy:H) were prepared by rf glow discharge decomposition of SiH4, NH3 and N2O gases, in a PECVD reactor provided with an in situ phase-modulated ellipsometer. The ratio [N2O]/([N2O] + [NH3]) was varied from 0 to 1 in a dilution with 5% of SiH4, keeping constant the total gas flow rate. From spectroscopic ellipsometric measurements, performed in the range 1.5–5.0 eV, the refractive index of the films was calculated applying the Bruggeman effective medium theory. The structural model used considers a three-component mixture layer, composed of void, silicon dioxide (glass) and silicon nitride (pyrolitic), on a c-Si substrate. The x and y composition parameters were calculated from the fitted relative volume fraction of each constituent, ranging from a-SiO2N0:H to a-SiO0)N1.33:H, which are in fair agreement with those obtained from XPS measurements. These results, along with data of FTIR spectra of the films show a clear correlation between the void fraction and the bonded hydrogen content of the films.

Composition Analysis of RF Plasma-Deposited Amorphous Silicon Oxynitride Thin Films by Spectroscopic Phase-Modulated Ellipsometry

A new thermodynamically consistent damage model is proposed for the simulation of high-cycle fatigue crack growth. The basis for the formulation is an interfacial degradation law that links Fracture Mechanics and Damage Mechanics to relate the evolution of the damage variable, d, with the crack growth rate da/dN. The damage state is a function of the loading conditions (R and (Delta)G) as well as the experimentally-determined crack growth rates for the material. The formulation ensures that the experimental results can be reproduced by the analysis without the need of additional adjustment parameters.

/pdf/simulation-of-delamination-under-high-cycle-fatigue-in-36qnihdo0s.pdf

Simulation of Delamination Under High Cycle Fatigue in Composite Materials Using Cohesive Models

Classification of measles breakthrough cases in an elimination setting using a comprehensive algorithm of laboratory results: why sensitive and specific IgM assays are important.

Josep Costa

Papers

Effect of ply-thickness on the impact response of interleaved thin-ply non-crimp-fabric laminates: X-ray tomography investigation

Early HCV viral kinetics after liver transplantation

Composition Analysis of RF Plasma-Deposited Amorphous Silicon Oxynitride Thin Films by Spectroscopic Phase-Modulated Ellipsometry

Simulation of Delamination Under High Cycle Fatigue in Composite Materials Using Cohesive Models

Classification of measles breakthrough cases in an elimination setting using a comprehensive algorithm of laboratory results: why sensitive and specific IgM assays are important.