J
Joseph D. Brain
Researcher at Harvard University
Publications - 253
Citations - 11529
Joseph D. Brain is an academic researcher from Harvard University. The author has contributed to research in topics: Lung & Lung injury. The author has an hindex of 59, co-authored 253 publications receiving 10890 citations. Previous affiliations of Joseph D. Brain include University of Washington & Drexel University.
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Journal ArticleDOI
Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women
Yi-Hsiang Hsu,Scott A. Venners,Henry Terwedow,Yan Feng,Tianhua Niu,Zhiping Li,Nan M. Laird,Joseph D. Brain,Steve Cummings,Mary L. Bouxsein,Cliff J. Rosen,Xiping Xu +11 more
TL;DR: Risks of osteoporosis, osteopenia, and nonspine fractures were significantly higher for subjects with higher percentage body fat independent of body weight, physical activity, and age.
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Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis
R. William Vandivier,Valerie A. Fadok,Peter R. Hoffmann,Donna L. Bratton,Churee Penvari,Kevin K. Brown,Joseph D. Brain,Frank J. Accurso,Peter M. Henson +8 more
TL;DR: In this article, neutrophil elastase cleaved the phosphatidylserine receptor, but not CD36 or CD32 (Fc gamma RII), implying a potential mechanism for delayed apoptotic cell clearance in vivo.
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Pulmonary distribution of particles given by intratracheal instillation or by aerosol inhalation.
TL;DR: The aerosol groups evidence more even distribution with preferential deposition in the apical lobes, while groups receiving intratracheal instillations demonstrated nonuniform distribution patterns with preferential depositing in the dependent portions of the lung.
Journal ArticleDOI
Deposition of Aerosol in the Respiratory Tract1–3
Joseph D. Brain,Peter A. Valberg +1 more
Journal ArticleDOI
Substrate stiffening promotes endothelial monolayer disruption through enhanced physical forces
Ramaswamy Krishnan,Darinka D. Klumpers,Chan Young Park,Kavitha Rajendran,Xavier Trepat,Jan van Bezu,Victor W.M. van Hinsbergh,Christopher V. Carman,Joseph D. Brain,Jeffrey J. Fredberg,James P. Butler,Geerten P. van Nieuw Amerongen +11 more
TL;DR: A central role of physical forces in EC gap formation is demonstrated and a novel physiological mechanism is highlighted, which in normal circumstances is compliant but during pathology becomes stiffer.