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Yi-Hsiang Hsu
Researcher at Harvard University
Publications - 158
Citations - 10688
Yi-Hsiang Hsu is an academic researcher from Harvard University. The author has contributed to research in topics: Genome-wide association study & Bone density. The author has an hindex of 44, co-authored 149 publications receiving 9154 citations. Previous affiliations of Yi-Hsiang Hsu include National Taiwan University & Broad Institute.
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Journal ArticleDOI
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans
Melina Claussnitzer,Simon N. Dankel,Kyoung-Han Kim,Gerald Quon,Wouter Meuleman,Christine Haugen,Viktoria Glunk,Isabel S. Sousa,Jacqueline L. Beaudry,Vijitha Puviindran,Nezar Abdennur,Jannel Liu,Per-Arne Svensson,Yi-Hsiang Hsu,Daniel J. Drucker,Gunnar Mellgren,Chi-chung Hui,Hans Hauner,Manolis Kellis,Manolis Kellis +19 more
TL;DR: The data indicate that the FTO allele associated with obesity represses mitochondrial thermogenesis in adipocyte precursor cells in a tissue-autonomous manner, and points to a pathway for adipocyte thermogenesis regulation involving ARID5B, rs1421085, IRX3, and IRX5, which, when manipulated, had pronounced pro-obesity and anti-ob obesity effects.
Journal ArticleDOI
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
Karol Estrada,Unnur Styrkarsdottir,Evangelos Evangelou,Yi-Hsiang Hsu,Emma L. Duncan,Evangelia E. Ntzani,Ling Oei,Omar M. E. Albagha,Najaf Amin,John P. Kemp,Daniel L. Koller,Guo Shuai Li,Ching-Ti Liu,Ryan L. Minster,Alireza Moayyeri,Liesbeth Vandenput,Dana Willner,Su-Mei Xiao,Laura M. Yerges-Armstrong,Hou-Feng Zheng,Nerea Alonso,Joel Eriksson,Candace M. Kammerer,Stephen Kaptoge,Paul Leo,Gudmar Thorleifsson,Scott Wilson,Scott Wilson,James F. Wilson,Ville Aalto,Ville Aalto,Markku Alen,Aaron K. Aragaki,Thor Aspelund,Zoe H. Dailiana,David Duggan,Melissa Nolan Garcia,Natalia Garcia-Giralt,Sylvie Giroux,Göran Hallmans,Lynne J. Hocking,L. B. Husted,Karen A. Jameson,Khusainova Ri,Ghi Su Kim,Charles Kooperberg,Theodora Koromila,Marcin Kruk,Marika Laaksonen,Andrea Z. LaCroix,Seung-Hun Lee,P. C. Leung,Joshua R. Lewis,Laura Masi,Simona Mencej-Bedrač,Tuan V. Nguyen,Tuan V. Nguyen,Xavier Nogués,Millan S. Patel,Janez Prezelj,Lynda M. Rose,Serena Scollen,Kristin Siggeirsdottir,Albert V. Smith,Olle Svensson,Stella Trompet,Olivia Trummer,Natasja M. van Schoor,Jean Woo,Kun Zhu,Susana Balcells,Maria Luisa Brandi,Brendan M. Buckley,Sulin Cheng,Claus Christiansen,Cyrus Cooper,George Dedoussis,Ian Ford,Morten Frost,Morten Frost,David Goltzman,Jesús González-Macías,Mika Kähönen,Magnus Karlsson,Elza Khusnutdinova,Jung-Min Koh,Panagoula Kollia,Bente L. Langdahl,William D. Leslie,Paul Lips,Östen Ljunggren,Roman S. Lorenc,Janja Marc,Dan Mellström,Barbara Obermayer-Pietsch,José M. Olmos,Ulrika Pettersson-Kymmer,David M. Reid,José A. Riancho,Paul M. Ridker,François Rousseau,P. Eline Slagboom,Nelson Ls Tang,Roser Urreizti,Wim Van Hul,Jorma Viikari,María T. Zarrabeitia,Yurii S. Aulchenko,Martha C. Castaño-Betancourt,Elin Grundberg,Elin Grundberg,Lizbeth Herrera,Thorvaldur Ingvarsson,Hrefna Johannsdottir,Tony Kwan,Rui Jian Li,Robert Luben,Carolina Medina-Gomez,Stefan T Palsson,Sjur Reppe,Jerome I. Rotter,Gunnar Sigurdsson,Joyce B. J. van Meurs,Dominique J. Verlaan,Frances M K Williams,Andrew R. Wood,Yanhua Zhou,Kaare M. Gautvik,Tomi Pastinen,Soumya Raychaudhuri,Soumya Raychaudhuri,Jane A. Cauley,Daniel I. Chasman,Graeme R. Clark,Steven R. Cummings,Patrick Danoy,Elaine M. Dennison,Richard Eastell,John A. Eisman,John A. Eisman,Vilmundur Gudnason,Albert Hofman,Rebecca D. Jackson,Graeme Jones,J. Wouter Jukema,Kay-Tee Khaw,Terho Lehtimäki,Yongmei Liu,Mattias Lorentzon,Eugene V. McCloskey,Braxton D. Mitchell,Kannabiran Nandakumar,Geoffrey C. Nicholson,Ben A. Oostra,Munro Peacock,Huibert A. P. Pols,Richard L. Prince,Olli T. Raitakari,Olli T. Raitakari,Ian R. Reid,John A Robbins,Philip N. Sambrook,Pak C. Sham,Alan R. Shuldiner,Frances A. Tylavsky,Cornelia M. van Duijn,Nicholas J. Wareham,L. Adrienne Cupples,Michael J. Econs,David M. Evans,Tamara B. Harris,Annie W.C. Kung,Bruce M. Psaty,Jonathan Reeve,Tim D. Spector,Elizabeth A. Streeten,M. Carola Zillikens,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Claes Ohlsson,David Karasik,J. Brent Richards,Matthew A. Brown,Kari Stefansson,Kari Stefansson,André G. Uitterlinden,Stuart H. Ralston,John P. A. Ioannidis,John P. A. Ioannidis,Douglas P. Kiel,Fernando Rivadeneira +190 more
TL;DR: Light is shed on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility and within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways.
Journal ArticleDOI
Twenty bone mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
Fernando Rivadeneira,Unnur Styrkarsdottir,Karol Estrada,Bjarni V. Halldorsson,Yi-Hsiang Hsu,J. Brent Richards,J. Brent Richards,M. Carola Zillikens,Fotini K. Kavvoura,Najaf Amin,Yurii S. Aulchenko,L. Adrienne Cupples,Panagiotis Deloukas,Serkalem Demissie,Elin Grundberg,Albert Hofman,Augustine Kong,David Karasik,Joyce B. J. van Meurs,Ben A. Oostra,Tomi Pastinen,Huibert A. P. Pols,Gunnar Sigurdsson,Nicole Soranzo,Nicole Soranzo,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Frances M K Williams,Scott Wilson,Scott Wilson,Yanhua Zhou,Stuart H. Ralston,Cornelia M. van Duijn,Tim D. Spector,Douglas P. Kiel,Kari Stefansson,John P. A. Ioannidis,John P. A. Ioannidis,André G. Uitterlinden +38 more
TL;DR: The many SNPs associated with BMD map to genes in signaling pathways with relevance to bone metabolism and highlight the complex genetic architecture that underlies osteoporosis and variation in BMD.
Journal ArticleDOI
Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women
Yi-Hsiang Hsu,Scott A. Venners,Henry Terwedow,Yan Feng,Tianhua Niu,Zhiping Li,Nan M. Laird,Joseph D. Brain,Steve Cummings,Mary L. Bouxsein,Cliff J. Rosen,Xiping Xu +11 more
TL;DR: Risks of osteoporosis, osteopenia, and nonspine fractures were significantly higher for subjects with higher percentage body fat independent of body weight, physical activity, and age.
Journal ArticleDOI
An atlas of genetic influences on osteoporosis in humans and mice
John A. Morris,John P. Kemp,John P. Kemp,Scott E. Youlten,Laetitia Laurent,John G. Logan,Ryan C. Chai,Nicholas A. Vulpescu,Vincenzo Forgetta,Aaron Kleinman,Sindhu T. Mohanty,C. Marcelo Sergio,Julian M.W. Quinn,Loan Nguyen-Yamamoto,Aimee Lee Luco,Jinchu Vijay,Marie-Michelle Simon,Albena Pramatarova,Carolina Medina-Gomez,Katerina Trajanoska,Elena J. Ghirardello,Natalie C. Butterfield,Katharine F. Curry,Victoria D. Leitch,Penny C. Sparkes,Anne-Tounsia Adoum,Naila S. Mannan,Davide Komla-Ebri,Andrea S. Pollard,Hannah F. Dewhurst,Thomas A D Hassall,Michael-John G. Beltejar,Douglas J. Adams,Suzanne M. Vaillancourt,Stephen Kaptoge,Paul A. Baldock,Cyrus Cooper,Cyrus Cooper,Cyrus Cooper,Jonathan Reeve,Evangelia E. Ntzani,Evangelia E. Ntzani,Evangelos Evangelou,Evangelos Evangelou,Claes Ohlsson,David Karasik,Fernando Rivadeneira,Douglas P. Kiel,Jonathan H Tobias,Celia L Gregson,Nicholas C. Harvey,Nicholas C. Harvey,Elin Grundberg,Elin Grundberg,David Goltzman,David J. Adams,Christopher J. Lelliott,David A. Hinds,Cheryl L. Ackert-Bicknell,Yi-Hsiang Hsu,Matthew T. Maurano,Peter I. Croucher,Graham R. Williams,J. H. Duncan Bassett,David M. Evans,David M. Evans,J. Brent Richards +66 more
TL;DR: This genetic atlas provides evidence linking associated SNPs to causal genes, offers new insight into osteoporosis pathophysiology, and highlights opportunities for drug development.