C
Chan Young Park
Researcher at Harvard University
Publications - 62
Citations - 3264
Chan Young Park is an academic researcher from Harvard University. The author has contributed to research in topics: Cell migration & Extracellular matrix. The author has an hindex of 20, co-authored 59 publications receiving 2716 citations. Previous affiliations of Chan Young Park include Seoul National University.
Papers
More filters
Journal ArticleDOI
Collective cell guidance by cooperative intercellular forces.
Dhananjay T. Tambe,C. Corey Hardin,Thomas E. Angelini,Kavitha Rajendran,Chan Young Park,Xavier Serra-Picamal,Enhua H. Zhou,Muhammad H. Zaman,James P. Butler,David A. Weitz,Jeffrey J. Fredberg,Xavier Trepat +11 more
TL;DR: Migrations of both endothelial and epithelial monolayers conform to this behavior, as do breast cancer cell lines before but not after the epithelial-mesenchymal transition, and collective migration in these diverse systems is seen to be governed by a simple but unifying physiological principle.
Journal ArticleDOI
Unjamming and cell shape in the asthmatic airway epithelium
Jin-Ah Park,Jae Hun Kim,Dapeng Bi,Jennifer A. Mitchel,Nader Taheri Qazvini,Nader Taheri Qazvini,Kelan G. Tantisira,Chan Young Park,Maureen McGill,Sae Hoon Kim,Bomi Gweon,Jacob Notbohm,Robert L. Steward,Stephanie Burger,Scott H. Randell,Alvin T. Kho,Dhananjay T. Tambe,Dhananjay T. Tambe,C. Corey Hardin,Stephanie A. Shore,Elliot Israel,David A. Weitz,Daniel J. Tschumperlin,Elizabeth P. Henske,Scott T. Weiss,M. Lisa Manning,James P. Butler,Jeffrey M. Drazen,Jeffrey J. Fredberg +28 more
TL;DR: Cell shape provides a rigorous structural signature for classification and investigation of bronchial epithelial layer jamming in asthma, and potentially in any process in disease or development in which epithelial dynamics play a prominent role.
Journal ArticleDOI
Reinforcement versus Fluidization in Cytoskeletal Mechanoresponsiveness
Ramaswamy Krishnan,Chan Young Park,Yu-chun Lin,Jere Mead,Richard T. Jaspers,Xavier Trepat,Guillaume Lenormand,Dhananjay T. Tambe,Alexander V. Smolensky,Andrew H. Knoll,James P. Butler,Jeffrey J. Fredberg +11 more
TL;DR: It is shown here that in loading conditions expected in most physiological circumstances the localized reinforcement response fails to scale up to the level of homogeneous cell stretch; fluidization trumps reinforcement.
Journal ArticleDOI
Universal behavior of the osmotically compressed cell and its analogy to the colloidal glass transition
Enhua H. Zhou,Xavier Trepat,Chan Young Park,Guillaume Lenormand,Madavi Oliver,Srboljub M. Mijailovich,C. Corey Hardin,David A. Weitz,James P. Butler,Jeffrey J. Fredberg +9 more
TL;DR: This work provides a means to probe the physical nature of the cytoplasm under compression, and leads to results that are universal across cell type, which suggests that compression-induced weakening of the network is overwhelmed by crowding-induced stiffening of the Cy toplasm.
Journal ArticleDOI
Substrate stiffening promotes endothelial monolayer disruption through enhanced physical forces
Ramaswamy Krishnan,Darinka D. Klumpers,Chan Young Park,Kavitha Rajendran,Xavier Trepat,Jan van Bezu,Victor W.M. van Hinsbergh,Christopher V. Carman,Joseph D. Brain,Jeffrey J. Fredberg,James P. Butler,Geerten P. van Nieuw Amerongen +11 more
TL;DR: A central role of physical forces in EC gap formation is demonstrated and a novel physiological mechanism is highlighted, which in normal circumstances is compliant but during pathology becomes stiffer.