J
Joseph D. Mougous
Researcher at University of Washington
Publications - 80
Citations - 10612
Joseph D. Mougous is an academic researcher from University of Washington. The author has contributed to research in topics: Type VI secretion system & Secretion. The author has an hindex of 46, co-authored 73 publications receiving 8990 citations. Previous affiliations of Joseph D. Mougous include University of California, Berkeley & Harvard University.
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Journal ArticleDOI
A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus
Joseph D. Mougous,Marianne E. Cuff,Stefan Raunser,Aimee Shen,M. Zhou,Casey A. Gifford,Andrew L. Goodman,Grazyna Joachimiak,Claudia L. Ordoñez,Stephen Lory,Thomas Walz,Andrzej Joachimiak,Andrzej Joachimiak,John J. Mekalanos +13 more
TL;DR: HSI-I likely contributes to the pathogenesis of P. aeruginosa in CF patients and is detected in pulmonary secretions of cystic fibrosis patients and Hcp1-specific antibodies in their sera, suggesting that the apparatus functions during chronic infections.
A Virulence Locus of Pseudomonas aeruginosa Encodes a Protein
Joseph D. Mougous,Marianne E. Cuff,Stefan Raunser,Aimee Shen,M. Zhou,Casey A. Gifford,Andrew L. Goodman,Grazyna Joachimiak,Stephen Lory,Thomas Walz,Andrzej Joachimiak,John J. Mekalanos +11 more
Journal ArticleDOI
A Type VI Secretion System of Pseudomonas aeruginosa Targets a Toxin to Bacteria
Rachel D. Hood,Pragya Singh,FoSheng Hsu,Tüzün Güvener,Mike A. Carl,Rex R.S. Trinidad,Julie M. Silverman,Brooks B. Ohlson,Kevin G. Hicks,Rachael L. Plemel,Mo Li,Sandra Schwarz,Wenzhuo Y. Wang,Alexey J. Merz,David R. Goodlett,Joseph D. Mougous +15 more
TL;DR: This demonstration that the H1-T6SS targets a toxin to bacteria helps reconcile the structural and evolutionary relationship between the T6SS and the bacteriophage tail and spike.
Journal ArticleDOI
Type VI secretion delivers bacteriolytic effectors to target cells
Alistair B. Russell,Rachel D. Hood,Nhat Khai Bui,Michele LeRoux,Waldemar Vollmer,Joseph D. Mougous +5 more
TL;DR: It is shown that the type VI secretion system of Pseudomonas aeruginosa breaches this barrier to deliver two effector proteins, Tse1 and Tse3, to the periplasm of recipient cells, indicating a mechanism for export whereby effectors do not access donor cellperiplasm in transit.
Journal ArticleDOI
Type VI secretion system effectors: poisons with a purpose
TL;DR: The type VI secretion system (T6SS) mediates interactions between a broad range of Gram-negative bacterial species and has been shown to be involved in both antagonistic and non-antagonistic behaviors as mentioned in this paper.