J
Joseph G. Cannon
Researcher at Georgia Regents University
Publications - 98
Citations - 13167
Joseph G. Cannon is an academic researcher from Georgia Regents University. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 50, co-authored 98 publications receiving 12853 citations. Previous affiliations of Joseph G. Cannon include Pennsylvania State University & United States Department of Agriculture.
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Journal ArticleDOI
The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells
Stefan Endres,Reza Ghorbani,V E Kelley,Kostis Georgilis,Gerhard Lonnemann,J.W.M. van der Meer,Joseph G. Cannon,T S Rogers,Mark S. Klempner,Peter C. Weber +9 more
TL;DR: It is concluded that the synthesis ofIL-1 beta, IL-1 alpha, and tumor necrosis factor can be suppressed by dietary supplementation with long-chain n-3 fatty acids.
Journal ArticleDOI
Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1
Charles A. Dinarello,Joseph G. Cannon,Sheldon M. Wolff,H A Bernheim,Bruce Beutler,Anthony Cerami,Irene S. Figari,Michael A. Palladino,O'connor John +8 more
TL;DR: These studies show that TNF (cachectin) is another endogenous pyrogen which, like IL-1 and IFN-alpha, directly stimulate hypothalamic PGE2 synthesis and is an endogenous inducer ofIL-1.
Journal ArticleDOI
Rheumatoid cachexia: cytokine-driven hypermetabolism accompanying reduced body cell mass in chronic inflammation.
Ronenn Roubenoff,Rebecca A. Roubenoff,Joseph G. Cannon,Joseph J. Kehayias,Hong Zhuang,Bess Dawson-Hughes,Charles A. Dinarello,Irwin H. Rosenberg +7 more
TL;DR: Loss of body cell mass is common in RA; cytokine production in RA is associated with altered energy metabolism and intake, despite a theoretically adequate diet; and TNF-alpha and IL-1 beta modulate energy metabolic and body composition in RA.
Journal ArticleDOI
Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects.
Simin Nikbin Meydani,M. P. Barklund,Sandra Liu,Mohsen Meydani,Richard A. Miller,Joseph G. Cannon,Frank D. Morrow,Ross E. Rocklin,Jeffrey B. Blumberg +8 more
TL;DR: Short-term vitamin E supplementation improves immune responsiveness in healthy elderly individuals; this effect appears to be mediated by a decrease in PGE2 and/or other lipid-peroxidation products.
Journal Article
Interleukin 1 induces interleukin 1. I: Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro
Charles A. Dinarello,Takashi Ikejima,S. J. C. Warner,Scott F. Orencole,Gerhard Lonnemann,Joseph G. Cannon,Peter Libby +6 more
TL;DR: The ability of IL-1 to participate in an amplification event by inducing its own gene expression leading to synthesis of biologically active and immunoreactiveIL-1-beta in human MNC in vitro is examined.