T
Takashi Ikejima
Researcher at Shenyang Pharmaceutical University
Publications - 259
Citations - 9730
Takashi Ikejima is an academic researcher from Shenyang Pharmaceutical University. The author has contributed to research in topics: Apoptosis & Silibinin. The author has an hindex of 47, co-authored 248 publications receiving 8850 citations. Previous affiliations of Takashi Ikejima include Tufts Medical Center & Tufts University.
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Journal ArticleDOI
Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition.
TL;DR: IL-1, like TNF, possesses the ability to induce hemodynamic and hematological changes typical of septic shock, and that the combination of IL-1 and TNF is more potent than either agent alone.
Journal Article
Interleukin 1 induces interleukin 1. I: Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro
Charles A. Dinarello,Takashi Ikejima,S. J. C. Warner,Scott F. Orencole,Gerhard Lonnemann,Joseph G. Cannon,Peter Libby +6 more
TL;DR: The ability of IL-1 to participate in an amplification event by inducing its own gene expression leading to synthesis of biologically active and immunoreactiveIL-1-beta in human MNC in vitro is examined.
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Concentrations of immunoreactive human tumor necrosis factor alpha produced by human mononuclear cells in vitro
J.W.M. van der Meer,Stefan Endres,Gerhard Lonnemann,Joseph G. Cannon,Takashi Ikejima,S. Okusawa,Jeffrey A. Gelfand,Charles A. Dinarello +7 more
TL;DR: The concentrations of tumor necrosis factor (TNF) produced by human peripheral blood mononuclear cells (MNC) were measured using a radioimmunoassay (RIA) for human TNF using a rabbit antiserum against human recombinant TNF, and Hu rTNF labeled with Na1251 by a modification of the chloramine T method.
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Silibinin prevents amyloid β peptide-induced memory impairment and oxidative stress in mice
Ping Lu,Ping Lu,Takayoshi Mamiya,Lingling Lu,Lingling Lu,Akihiro Mouri,Li Bo Zou,Taku Nagai,Masayuki Hiramatsu,Takashi Ikejima,Toshitaka Nabeshima +10 more
TL;DR: The effect of silibinin on the memory impairment and accumulation of oxidative stress induced by Aβ25–35 in mice is examined.
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Induction of human interleukin-1 by a product of Staphylococcus aureus associated with toxic shock syndrome.
TL;DR: It is concluded that in TSS the sudden fever and probably other components of the acute phase response may be attributed to a massive release of IL-1.