J
Joseph H. Sommer
Researcher at National Institutes of Health
Publications - 7
Citations - 576
Joseph H. Sommer is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Myoglobin & Fluorescence anisotropy. The author has an hindex of 6, co-authored 7 publications receiving 566 citations.
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Journal ArticleDOI
Geminate recombination of carbon monoxide to myoglobin
TL;DR: Comparison of the two results using the simplest kinetic model suggests that the 30-fold more rapid overall association rate for the reaction of oxygen with myoglobin compared to carbon monoxide results mainly from faster binding at the heme, with a small contribution from more rapid entry of oxygen into the protein from the solvent.
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Nanosecond absorption spectroscopy of hemoglobin: elementary processes in kinetic cooperativity.
TL;DR: The rapid escape of CO from the heme pocket compared with the rate of rebinding observed for both R and T quaternARY states shows that the quaternary structure controls the overall dissociation rate by changing the rate at which the Fe--CO bond is broken.
Journal ArticleDOI
Nanosecond optical spectra of iron-cobalt hybrid hemoglobins: geminate recombination, conformational changes, and intersubunit communication.
James Hofrichter,Eric R. Henry,Joseph H. Sommer,Robert Deutsch,Masao Ikeda-Saito,Takashi Yonetani,William A. Eaton +6 more
TL;DR: Comparison of the deoxyheme spectral changes and relaxation times among the three molecules indicated that both alpha and beta subunits contribute to the de OxyheME spectral changes that signal tertiary and quaternary conformational changes in the unsubstituted tetramer.
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Fluorescence polarization decay of tyrosine in lima bean trypsin inhibitor
TL;DR: The data argue that this interior portion of the protein consists of a rigid, immobile backbone embedded in fluid, mobile amino acid side chains.