J
Joseph L. Kim
Researcher at Amgen
Publications - 71
Citations - 5790
Joseph L. Kim is an academic researcher from Amgen. The author has contributed to research in topics: Hepatitis C virus & Cancer. The author has an hindex of 28, co-authored 69 publications receiving 5586 citations. Previous affiliations of Joseph L. Kim include Howard Hughes Medical Institute & Vertex Pharmaceuticals.
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Journal ArticleDOI
Co-crystal structure of TBP recognizing the minor groove of a TATA element
TL;DR: The three-dimensional structure of a TATA-box binding polypeptide complexed with the TATA element of the adenovirus major late promoter has been determined by X-ray crystallography at 2.25 Å resolution.
Journal ArticleDOI
X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex
James P. Griffith,Joseph L. Kim,Eunice E. Kim,Michael D. Sintchak,John A. Thomson,Matthew J. Fitzgibbon,Mark A. Fleming,Paul R. Caron,Kathy Hsiao,Manuel A. Navia +9 more
TL;DR: The ternary complex described here represents the three-dimensional structure of a Ser/Thr protein phosphatase and provides a structural basis for understanding calcineurin inhibition by FKBP12-FK506.
Journal ArticleDOI
Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide.
Joseph L. Kim,Morgenstern Kurt A,Chao Lin,Ted Fox,Maureen D. Dwyer,J. A. Landro,Stephen P. Chambers,William Markland,Christopher A. Lepre,Ethan O'malley,Scott L. Harbeson,Charles M. Rice,Murcko Mark A,Paul R. Caron,John A. Thomson +14 more
TL;DR: The 2.5 angstrom resolution X-ray crystal structure of the NS3 protease domain complexed with a synthetic NS4A activator peptide is reported, which shows a chymotrypsin-like fold and features a tetrahedrally coordinated metal ion distal to the active site.
Journal ArticleDOI
Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding
Joseph L. Kim,Morgenstern Kurt A,James P. Griffith,Maureen D. Dwyer,John A. Thomson,Murcko Mark A,Chao Lin,Paul R. Caron +7 more
TL;DR: The structure of the HCV NS3 RNA helicase domain complexed with a single-stranded DNA oligonucleotide has been solved to 2.2 A resolution and is a member of a superfamily of helicases, termed superfamily II.
Journal ArticleDOI
TATA Element Recognition by the TATA Box-Binding Protein Has Been Conserved Throughout Evolution
Georgia A. Patikoglou,Joseph L. Kim,Liping Sun,Sang-Hwa Yang,Thomas Kodadek,Stephen K. Burley +5 more
TL;DR: It is concluded that the structure of the TBP-TATA box complex found at the heart of the polymerase II (pol II) transcription machinery has remained constant over the course of evolution, despite variations in TBP and its DNA targets.