P
Paul R. Caron
Researcher at Vertex Pharmaceuticals
Publications - 35
Citations - 6063
Paul R. Caron is an academic researcher from Vertex Pharmaceuticals. The author has contributed to research in topics: Hepatitis C virus & MAP kinase kinase kinase. The author has an hindex of 19, co-authored 35 publications receiving 5904 citations.
Papers
More filters
Journal ArticleDOI
The structural basis for 14-3-3:phosphopeptide binding specificity.
Michael B. Yaffe,Katrin Rittinger,Stefano Volinia,Paul R. Caron,Alastair Aitken,Henrik Leffers,Steven J. Gamblin,Stephen J. Smerdon,Lewis C. Cantley,Lewis C. Cantley +9 more
TL;DR: It is shown that the 14-3-3 dimer binds tightly to single molecules containing tandem repeats of phosphoserine motifs, implicating bidentate association as a signaling mechanism with molecules such as Raf, BAD, and Cbl.
Journal ArticleDOI
X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex
James P. Griffith,Joseph L. Kim,Eunice E. Kim,Michael D. Sintchak,John A. Thomson,Matthew J. Fitzgibbon,Mark A. Fleming,Paul R. Caron,Kathy Hsiao,Manuel A. Navia +9 more
TL;DR: The ternary complex described here represents the three-dimensional structure of a Ser/Thr protein phosphatase and provides a structural basis for understanding calcineurin inhibition by FKBP12-FK506.
Journal ArticleDOI
Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide.
Joseph L. Kim,Morgenstern Kurt A,Chao Lin,Ted Fox,Maureen D. Dwyer,J. A. Landro,Stephen P. Chambers,William Markland,Christopher A. Lepre,Ethan O'malley,Scott L. Harbeson,Charles M. Rice,Murcko Mark A,Paul R. Caron,John A. Thomson +14 more
TL;DR: The 2.5 angstrom resolution X-ray crystal structure of the NS3 protease domain complexed with a synthetic NS4A activator peptide is reported, which shows a chymotrypsin-like fold and features a tetrahedrally coordinated metal ion distal to the active site.
Journal ArticleDOI
Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding
Joseph L. Kim,Morgenstern Kurt A,James P. Griffith,Maureen D. Dwyer,John A. Thomson,Murcko Mark A,Chao Lin,Paul R. Caron +7 more
TL;DR: The structure of the HCV NS3 RNA helicase domain complexed with a single-stranded DNA oligonucleotide has been solved to 2.2 A resolution and is a member of a superfamily of helicases, termed superfamily II.
Journal ArticleDOI
Structure and Mechanism of Inosine Monophosphate Dehydrogenase in Complex with the Immunosuppressant Mycophenolic Acid
Michael D. Sintchak,Mark A. Fleming,Olga Futer,Scott A. Raybuck,Stephen P. Chambers,Paul R. Caron,Murcko Mark A,Wilson Keith P +7 more
TL;DR: The structure of inosine-5'-monophosphate dehydrogenase in complex with IMP and mycophenolic acid (MPA) has been determined by X-ray diffraction and indicates that MPA inhibits IMPDH by acting as a replacement for the Nicotinamide portion of the nicotinamide adenine dinucleotide cofactor and a catalytic water molecule.