J
Joseph L. Milburn
Researcher at University of Texas Southwestern Medical Center
Publications - 11
Citations - 1539
Joseph L. Milburn is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Insulin & Glucose transporter. The author has an hindex of 10, co-authored 11 publications receiving 1510 citations. Previous affiliations of Joseph L. Milburn include Tohoku University & University of Geneva.
Papers
More filters
Journal ArticleDOI
Efficacy and Safety of Inhaled Insulin (Exubera) Compared With Subcutaneous Insulin Therapy in Patients With Type 2 Diabetes: Results of a 6-month, randomized, comparative trial
Priscilla Hollander,Lawrence Blonde,Richard Rowe,Adi E. Mehta,Joseph L. Milburn,Kenneth S. Hershon,Jean Louis Chiasson,Seymour R. Levin +7 more
TL;DR: Inhaled insulin appears to be effective, well tolerated, and well accepted in patients with type 2 diabetes and provides glycemic control comparable to a conventional subcutaneous regimen.
Journal ArticleDOI
Pancreatic β-Cells in Obesity: EVIDENCE FOR INDUCTION OF FUNCTIONAL, MORPHOLOGIC, AND METABOLIC ABNORMALITIES BY INCREASED LONG CHAIN FATTY ACIDS (∗)
Joseph L. Milburn,Hiroshi Hirose,Young H Lee,Yoshitaka Nagasawa,Atsushi Ogawa,M. Ohneda,Hector BeltrandelRio,Christopher B. Newgard,John H. Johnson,John H. Johnson,Roger H Unger,Roger H Unger +11 more
TL;DR: It is concluded that hypersecretion of insulin by islets of obese Zucker fatty rats is associated with, and probably caused by, enhanced low Km glucose metabolism and beta-cell hyperplasia, abnormalities that can be induced in normal islets by increased FFA.
Journal ArticleDOI
The high Km glucose transporter of islets of Langerhans is functionally similar to the low affinity transporter of liver and has an identical primary sequence.
TL;DR: Sequence analysis of cDNA clones indicates that the liver and islet glucose transporters have identical sequences and, thus, are the products of the same gene.
Journal ArticleDOI
Differential expression and regulation of the glucokinase gene in liver and islets of Langerhans
Patrick B. Iynedjian,Paul-Richard Pilot,Thierry Nouspikel,Joseph L. Milburn,Christian Quaade,Steven D. Hughes,Catherine Ucla,Christopher B. Newgard +7 more
TL;DR: It is concluded that alternative splicing and/or the use of distinct tissue-specific promoters generate structurally distinct mRNA species in liver and islets of Langerhans and that tissue- specific transcription mechanisms result in inducible expression of the glucokinase gene in liver but not in islets during the fasting-refeeding transition.
Journal ArticleDOI
Role of peroxisome proliferator-activated receptor α in disease of pancreatic β cells
Yan Ting Zhou,Michio Shimabukuro,Michio Shimabukuro,May-Yun Wang,Young H Lee,Moritake Higa,Moritake Higa,Joseph L. Milburn,Christopher B. Newgard,Roger H Unger +9 more
TL;DR: In this paper, the peroxisome proliferator-activated receptor α (PPARα) and enzymes of fatty acid (FA) oxidation is markedly reduced in the fat-laden, dysfunctional islets of obese, prediabetic Zucker diabetic fatty (fa/fa) rats with mutated leptin receptors (OB-R).