J
Joseph M. DeSimone
Researcher at University of North Carolina at Chapel Hill
Publications - 636
Citations - 40706
Joseph M. DeSimone is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Supercritical carbon dioxide & Supercritical fluid. The author has an hindex of 94, co-authored 628 publications receiving 37761 citations. Previous affiliations of Joseph M. DeSimone include National Science Foundation & Memorial Sloan Kettering Cancer Center.
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Journal ArticleDOI
Strategies in the design of nanoparticles for therapeutic applications
TL;DR: This Review focuses on recent progress important for the rational design of such nanoparticles and discusses the challenges to realizing the potential of nanoparticles.
Journal ArticleDOI
The effect of particle design on cellular internalization pathways
Stephanie E. A. Gratton,Patricia A. Ropp,Patrick D. Pohlhaus,J. Christopher Luft,Victoria J. Madden,Mary E. Napier,Joseph M. DeSimone +6 more
TL;DR: These findings suggest that HeLa cells readily internalize nonspherical particles with dimensions as large as 3 μm by using several different mechanisms of endocytosis, and it was found that rod-like particles enjoy an appreciable advantage when it comes to internalization rates.
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Continuous liquid interface production of 3D objects
John R. Tumbleston,David Shirvanyants,Nikita Ermoshkin,Rima Janusziewicz,Ashley R. Johnson,David L. Kelly,Kai Chen,Robert Pinschmidt,Jason P. Rolland,Alexander Ermoshkin,Edward T. Samulski,Joseph M. DeSimone,Joseph M. DeSimone +12 more
TL;DR: The continuous generation of monolithic polymeric parts up to tens of centimeters in size with feature resolution below 100 micrometers is demonstrated and critical control parameters are delineated and shown that complex solid parts can be drawn out of the resin at rates of hundreds of millimeters per hour.
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Practical approaches to green solvents
TL;DR: This report highlights opportunities for the practical implementation of green solvents in the manufacturing and service industries through the development of solvent-free processes and more efficient recycling protocols.
Journal ArticleDOI
Direct Fabrication and Harvesting of Monodisperse, Shape-Specific Nanobiomaterials
Jason P. Rolland,Benjamin W. Maynor,Larken E. Euliss,Ansley E. Exner,Ginger M. Denison,Joseph M. DeSimone +5 more
TL;DR: Particle Replication In Nonwetting Templates affords the simple, straightforward encapsulation of a variety of important bioactive agents, including proteins, DNA, and small-molecule therapeutics, which indicates that PRINT can be used to fabricate next-generation particulate drug-delivery agents.