J
Joseph P. St. Laurent
Publications - 25
Citations - 474
Joseph P. St. Laurent is an academic researcher. The author has contributed to research in topics: Oral administration & Acne. The author has an hindex of 6, co-authored 25 publications receiving 327 citations.
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Journal ArticleDOI
OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.
Carlo Marchetti,Benjamin J Swartzwelter,Fabia Gamboni,Charles Preston Neff,Katrin Richter,Tania Azam,Sonia Carta,Isak W. Tengesdal,Travis Nemkov,Angelo D'Alessandro,Curtis J. Henry,Gerald S. Jones,Scott A. Goodrich,Joseph P. St. Laurent,Terry M. Jones,Curtis L. Scribner,Robert B. Barrow,Roy D. Altman,Damaris B. Skouras,Marco Gattorno,Veronika Grau,Sabina Janciauskiene,Anna Rubartelli,Leo A. B. Joosten,Charles A. Dinarello,Charles A. Dinarello +25 more
TL;DR: It is demonstrated that OLT1177, an orally active β-sulfonyl nitrile molecule, inhibits activation of the NLRP3 inflammasome, with unique properties to reverse the metabolic costs of inflammation and to treat IL-1β– and IL-18–mediated diseases.
Journal ArticleDOI
Cannabis Vaporizer Combines Efficient Delivery of THC with Effective Suppression of Pyrolytic Compounds
TL;DR: In this article, the authors evaluated the efficacy of an herbal vaporizer known as the Volcano ®, produced by Storz & Bickel GmbH&Co. KG, Tuttlingen, Germany.
Patent
Synthesis of fatty alcohol esters of alpha-hydroxy carboxylic acids, the use of the same as percutaneous permeation enhancers, and topical gels for the transdermal delivery of steroids
TL;DR: In this article, a topical gel for the transdermal delivery of steroids using the fatty alcohol esters as permeation enhancers was proposed. But it is not suitable for topical application.
Patent
Compounds for treating inflammation and pain
TL;DR: In this article, a compound of 2-N halo-4-methylsulfonyl-butyric acid (Halo-SSA) was proposed for treating inflammatory or inflammatory-related disorders, bacterial infection, pain, or skin conditions.
Patent
Synthesis of fatty alcohol esters of alpha-hydroxy carboxylic acids and their use as percutaneous absorption enhancers
TL;DR: In this paper, the transesterification of α-hydroxy carboxylic acid (α-HOCA) was used to transform a lower alkyl ester into a fatty alcohol ester via alcoholysis.