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Isak W. Tengesdal
Researcher at University of Colorado Denver
Publications - 19
Citations - 900
Isak W. Tengesdal is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Inflammasome & Inflammation. The author has an hindex of 9, co-authored 14 publications receiving 467 citations. Previous affiliations of Isak W. Tengesdal include Radboud University Nijmegen Medical Centre & University of Colorado Boulder.
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Journal ArticleDOI
OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.
Carlo Marchetti,Benjamin J Swartzwelter,Fabia Gamboni,Charles Preston Neff,Katrin Richter,Tania Azam,Sonia Carta,Isak W. Tengesdal,Travis Nemkov,Angelo D'Alessandro,Curtis J. Henry,Gerald S. Jones,Scott A. Goodrich,Joseph P. St. Laurent,Terry M. Jones,Curtis L. Scribner,Robert B. Barrow,Roy D. Altman,Damaris B. Skouras,Marco Gattorno,Veronika Grau,Sabina Janciauskiene,Anna Rubartelli,Leo A. B. Joosten,Charles A. Dinarello,Charles A. Dinarello +25 more
TL;DR: It is demonstrated that OLT1177, an orally active β-sulfonyl nitrile molecule, inhibits activation of the NLRP3 inflammasome, with unique properties to reverse the metabolic costs of inflammation and to treat IL-1β– and IL-18–mediated diseases.
Journal ArticleDOI
Dapansutrile, an oral selective NLRP3 inflammasome inhibitor, for treatment of gout flares: an open-label, dose-adaptive, proof-of-concept, phase 2a trial
Viola Klück,T.L.Th.A. Jansen,Matthijs Janssen,Antoaneta Comarniceanu,M. Efde,Isak W. Tengesdal,Kiki Schraa,Maartje C. P. Cleophas,Curtis L. Scribner,Damaris B. Skouras,Carlo Marchetti,Charles A. Dinarello,Charles A. Dinarello,Leo A. B. Joosten,Leo A. B. Joosten +14 more
TL;DR: Dapansutrile is a specific NLRP3 inflammasome inhibitor with a satisfactory safety profile and efficacy in the reduction of target joint pain in this study.
Journal ArticleDOI
NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis.
Carlo Marchetti,Benjamin J Swartzwelter,Marije I. Koenders,Tania Azam,Isak W. Tengesdal,Isak W. Tengesdal,Nick Powers,Dennis M. de Graaf,Dennis M. de Graaf,Charles A. Dinarello,Charles A. Dinarello,Leo A. B. Joosten,Leo A. B. Joosten +12 more
TL;DR: Oral OLT1177 is highly effective in ameliorating reactive as well as gouty arthritis in murine acute arthritis models and correlated dose-dependently with reduction in joint inflammation.
Journal ArticleDOI
MHC class II super-enhancer increases surface expression of HLA-DR and HLA-DQ and affects cytokine production in autoimmune vitiligo
Giulio Cavalli,Giulio Cavalli,Masahiro Hayashi,Ying Jin,Daniel Yorgov,Stephanie A. Santorico,Cherie Holcomb,Melinda Rastrou,Henry A. Erlich,Isak W. Tengesdal,Lorenzo Dagna,C. Preston Neff,Brent E. Palmer,Richard A. Spritz,Charles A. Dinarello,Charles A. Dinarello +15 more
TL;DR: It is demonstrated that for risk of autoimmune vitiligo, expression level of HLA class II molecules is as or more important than antigen specificity, tying together genetic variation in the MHC with the development of autoimmunity.
Journal ArticleDOI
Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion
Isak W. Tengesdal,Isak W. Tengesdal,Dinoop Ravindran Menon,Douglas G. Osborne,Charles Preston Neff,Nicholas E. Powers,Fabia Gamboni,Adolfo G Mauro,Angelo D'Alessandro,Davide Stefanoni,Morkos A. Henen,Morkos A. Henen,Taylor S. Mills,Dennis M. de Graaf,Dennis M. de Graaf,Tania Azam,Beat Vögeli,Brent E. Palmer,Eric M. Pietras,James DeGregori,Aik Choon Tan,Leo A. B. Joosten,Mayumi Fujita,Charles A. Dinarello,Charles A. Dinarello,Carlo Marchetti +25 more
TL;DR: In this paper, the formation of the pyrin domain-containing-3 (NLRP3) inflammasome activation in melanoma is linked to IL-1β production, inflammation, and immunosuppression.