T
Travis Nemkov
Researcher at University of Colorado Denver
Publications - 158
Citations - 6650
Travis Nemkov is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 38, co-authored 124 publications receiving 3994 citations. Previous affiliations of Travis Nemkov include Anschutz Medical Campus & University of Colorado Boulder.
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Journal ArticleDOI
COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status.
Tiffany Thomas,Davide Stefanoni,Julie A. Reisz,Travis Nemkov,Lorenzo Bertolone,Richard O. Francis,Krystalyn E. Hudson,James C. Zimring,Kirk C. Hansen,Eldad A. Hod,Steven L. Spitalnik,Angelo D'Alessandro +11 more
TL;DR: This initial observational study identified amino acid and fatty acid metabolism as correlates of COVID-19, providing mechanistic insights, potential markers of clinical severity, and potential therapeutic targets.
Journal ArticleDOI
Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells.
Courtney L. Jones,Brett M. Stevens,Angelo D'Alessandro,Julie A. Reisz,Rachel Culp-Hill,Travis Nemkov,Shanshan Pei,Nabilah Khan,Biniam Adane,Haobin Ye,Anna Krug,Dominik Reinhold,Clayton A. Smith,James DeGregori,Daniel A. Pollyea,Craig T. Jordan +15 more
TL;DR: It is demonstrated that amino acid uptake, steady-state levels, and catabolism are all elevated in the leukemia stem cell (LSC) population, indicating that clinically relevant eradication of LSCs can be achieved with drugs that target LSC metabolic vulnerabilities.
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OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.
Carlo Marchetti,Benjamin J Swartzwelter,Fabia Gamboni,Charles Preston Neff,Katrin Richter,Tania Azam,Sonia Carta,Isak W. Tengesdal,Travis Nemkov,Angelo D'Alessandro,Curtis J. Henry,Gerald S. Jones,Scott A. Goodrich,Joseph P. St. Laurent,Terry M. Jones,Curtis L. Scribner,Robert B. Barrow,Roy D. Altman,Damaris B. Skouras,Marco Gattorno,Veronika Grau,Sabina Janciauskiene,Anna Rubartelli,Leo A. B. Joosten,Charles A. Dinarello,Charles A. Dinarello +25 more
TL;DR: It is demonstrated that OLT1177, an orally active β-sulfonyl nitrile molecule, inhibits activation of the NLRP3 inflammasome, with unique properties to reverse the metabolic costs of inflammation and to treat IL-1β– and IL-18–mediated diseases.
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Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Patients with Acute Myeloid Leukemia.
Shanshan Pei,Daniel A. Pollyea,Annika Gustafson,Brett M. Stevens,Mohammad Minhajuddin,Rui Fu,Kent Riemondy,Austin E. Gillen,Ryan M. Sheridan,Jihye Kim,James C. Costello,Maria L. Amaya,Anagha Inguva,Amanda Winters,Haobin Ye,Anna Krug,Courtney L. Jones,Biniam Adane,Nabilah Khan,J Ponder,Jeffrey Schowinsky,Diana Abbott,Andrew Hammes,Jason R. Myers,John M. Ashton,Travis Nemkov,Angelo D'Alessandro,Jonathan A. Gutman,Haley E. Ramsey,Michael R. Savona,Clayton A. Smith,Craig T. Jordan +31 more
TL;DR: It is concluded that resistance to venetoclax + azacitidine can arise due to biological properties intrinsic to monocytic differentiation, and it is proposed that optimal AML therapies should be designed so as to independently target AML subclones that may arise at differing stages of pathogenesis.
Journal ArticleDOI
A TDO2-AhR signaling axis facilitates anoikis resistance and metastasis in triple-negative breast cancer.
Nicholas C. D'Amato,Thomas J. Rogers,Michael A. Gordon,Lisa I. Greene,Dawn R. Cochrane,Nicole S. Spoelstra,Travis Nemkov,Angelo D'Alessandro,Kirk C. Hansen,Jennifer K. Richer +9 more
TL;DR: An NF-κB-regulated signaling axis that promotes anoikis resistance is defined, functional connections with inflammatory modulation by the kynurenine pathway are suggested, and TDO2 is highlighted as an attractive target for treatment of this aggressive breast cancer subtype.