J
Joshua A. Bueller
Researcher at University of California, Los Angeles
Publications - 26
Citations - 5872
Joshua A. Bueller is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Anterior cingulate cortex & Irritable bowel syndrome. The author has an hindex of 21, co-authored 26 publications receiving 5492 citations. Previous affiliations of Joshua A. Bueller include Mental Health Research Institute & University of California, Irvine.
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Journal ArticleDOI
COMT val158met Genotype Affects µ-Opioid Neurotransmitter Responses to a Pain Stressor
Jon Kar Zubieta,Mary M. Heitzeg,Yolanda R. Smith,Joshua A. Bueller,Ke Xu,Yanjun Xu,Robert A. Koeppe,Christian S. Stohler,David Goldman +8 more
TL;DR: Individuals homozygous for themet158 allele of the catechol-O-methyltransferase (COMT) polymorphism showed diminished regional μ-opioid system responses to pain compared with heterozygotes, and these effects were accompanied by higher sensory and affective ratings of pain and a more negative internal affective state.
Journal ArticleDOI
Regional mu opioid receptor regulation of sensory and affective dimensions of pain.
Jon Kar Zubieta,Yolanda R. Smith,Joshua A. Bueller,Yanjun Xu,Michael R. Kilbourn,Douglas M. Jewett,Charles R. Meyer,Robert A. Koeppe,Christian S. Stohler +8 more
TL;DR: Sustained pain induced the regional release of endogenous opioids interacting with μ-opioid receptors in a number of cortical and subcortical brain regions, resulting in reductions in the sensory and affective ratings of the pain experience.
Journal ArticleDOI
Placebo Effects Mediated by Endogenous Opioid Activity on μ-Opioid Receptors
Jon Kar Zubieta,Joshua A. Bueller,Lisa R. Jackson,D. Scott,Yanjun Xu,Robert A. Koeppe,Thomas E. Nichols,Christian S. Stohler +7 more
TL;DR: Cognitive factors (e.g., expectation of pain relief) are capable of modulating physical and emotional states through the site-specific activation of μ-opioid receptor signaling in the human brain.
Journal ArticleDOI
BDNF Val66Met Allele Is Associated with Reduced Hippocampal Volume in Healthy Subjects
Joshua A. Bueller,Macksood Aftab,Srijan Sen,Diana Gomez-Hassan,Margit Burmeister,Jon Kar Zubieta +5 more
TL;DR: The presence of the met-BDNF allele was found associated with a reduced volume of the hippocampal formation in healthy volunteers and may represent a vulnerability factor for the development of disease processes associated with the dysfunction of this brain region.
Journal ArticleDOI
Regulation of Human Affective Responses by Anterior Cingulate and Limbic µ-Opioid Neurotransmission
Jon Kar Zubieta,Terence A. Ketter,Joshua A. Bueller,Yanjun Xu,Michael R. Kilbourn,Elizabeth A. Young,Robert A. Koeppe +6 more
TL;DR: The role of the mu-opioid receptor system in the physiological regulation of affective experiences in humans is confirmed and dynamic changes in mu-OPioid neurotransmission in response to an experimentally induced negative affective state are demonstrated.