Journal ArticleDOI
COMT val158met Genotype Affects µ-Opioid Neurotransmitter Responses to a Pain Stressor
Jon Kar Zubieta,Mary M. Heitzeg,Yolanda R. Smith,Joshua A. Bueller,Ke Xu,Yanjun Xu,Robert A. Koeppe,Christian S. Stohler,David Goldman +8 more
TLDR
Individuals homozygous for themet158 allele of the catechol-O-methyltransferase (COMT) polymorphism showed diminished regional μ-opioid system responses to pain compared with heterozygotes, and these effects were accompanied by higher sensory and affective ratings of pain and a more negative internal affective state.Abstract:
Responses to pain and other stressors are regulated by interactions between multiple brain areas and neurochemical systems. We examined the influence of a common functional genetic polymorphism affecting the metabolism of catecholamines on the modulation of responses to sustained pain in humans. Individuals homozygous for the met 158 allele of the catechol- O -methyltransferase (COMT) polymorphism ( val 158 met ) showed diminished regional μ-opioid system responses to pain compared with heterozygotes. These effects were accompanied by higher sensory and affective ratings of pain and a more negative internal affective state. Opposite effects were observed in val 158 homozygotes. The COMT val 158 met polymorphism thus influences the human experience of pain and may underlie interindividual differences in the adaptation and responses to pain and other stressful stimuli.read more
Citations
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Persistent postsurgical pain: risk factors and prevention
TL;DR: Strategies for identification of patients at risk and for prevention and possible treatment of this important entity of chronic pain are outlined.
Journal ArticleDOI
Human brain mechanisms of pain perception and regulation in health and disease.
TL;DR: A systematic review of the literature regarding how activity in diverse brain regions creates and modulates the experience of acute and chronic pain states, emphasizing the contribution of various imaging techniques to emerging concepts is presented in this paper.
Journal ArticleDOI
The Cerebral Signature for Pain Perception and Its Modulation
Irene Tracey,Patrick W. Mantyh +1 more
TL;DR: It is suggested that the brainstem plays a pivotal role in gating the degree of nociceptive transmission so that the resultant pain experienced is appropriate for the particular situation of the individual.
Journal ArticleDOI
Chronic Back Pain Is Associated with Decreased Prefrontal and Thalamic Gray Matter Density
A. Vania Apkarian,Yamaya Sosa,Sreepadma P. Sonty,Robert M. Levy,R. Norman Harden,Todd B. Parrish,Darren R. Gitelman +6 more
TL;DR: In this paper, brain morphology of 26 chronic back pain patients to matched control subjects was compared using magnetic resonance imaging brain scan data and automated analysis techniques, using voxel-based morphometry and nonparametric statistics.
Journal ArticleDOI
Genetic basis for individual variations in pain perception and the development of a chronic pain condition
Luda Diatchenko,Gary D. Slade,Andrea G. Nackley,Konakporn Bhalang,Asgeir Sigurdsson,Inna Belfer,David Goldman,Ke Xu,Svetlana A. Shabalina,Dmitry A. Shagin,Mitchell B. Max,Sergei S. Makarov,William Maixner +12 more
TL;DR: Three genetic variants of the gene encoding catecholamine-O-methyltransferase determine COMT activity in humans that inversely correlates with pain sensitivity and the risk of developing TMD.
References
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Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia.
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