J
Joshua C. Brown
Researcher at Medical University of South Carolina
Publications - 24
Citations - 389
Joshua C. Brown is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Medicine & Long-term potentiation. The author has an hindex of 7, co-authored 10 publications receiving 241 citations. Previous affiliations of Joshua C. Brown include Medical College of Wisconsin.
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Journal ArticleDOI
Neurophysiologic effects of transcutaneous auricular vagus nerve stimulation (taVNS) via electrical stimulation of the tragus: A concurrent taVNS/fMRI study and review.
Bashar W. Badran,Logan T. Dowdle,Oliver J. Mithoefer,Nicholas T. LaBate,James Coatsworth,Joshua C. Brown,William H. DeVries,Christopher W. Austelle,Lisa M. McTeague,Mark S. George +9 more
TL;DR: Stimulation of the tragus activates the cerebral afferents of the vagal pathway and combined with the review of the literature suggest that taVNS is a promising form of VNS.
Journal ArticleDOI
Tragus or cymba conchae? Investigating the anatomical foundation of transcutaneous auricular vagus nerve stimulation (taVNS).
Bashar W. Badran,Joshua C. Brown,Logan T. Dowdle,Oliver J. Mithoefer,Nicholas T. LaBate,James Coatsworth,William H. DeVries,Christopher W. Austelle,Lisa M. McTeague,Alfred B. Yu,Marom Bikson,Dorothea Jenkins,Mark S. George +12 more
TL;DR: This research highlights the need to understand more fully the role of emotion in the development of central nervous system disorders and the role that emotion plays in the decision-making process.
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Bidirectional regulation of synaptic transmission by BRAG1/IQSEC2 and its requirement in long-term depression.
Joshua C. Brown,Amber Petersen,Ling Zhong,Miranda L. Himelright,Jessica A. Murphy,Randall S. Walikonis,Nashaat Z. Gerges +6 more
TL;DR: A dual role of BRAG1 in synaptic function is demonstrated and the functional relevance of reduced BRAG2 Arf-GEF activity is highlighted as seen in the XLID-associated human mutations.
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NMDA receptor partial agonist, d-cycloserine, enhances 10 Hz rTMS-induced motor plasticity, suggesting long-term potentiation (LTP) as underlying mechanism.
Joshua C. Brown,William H. DeVries,Jeffrey E. Korte,Gregory L. Sahlem,Leonardo Bonilha,E. Baron Short,Mark S. George +6 more
TL;DR: It is hypothesized that 10 Hz rTMS enhances motor excitability through NMDA receptor-dependent LTP of glutamatergic synapses, and that partial agonism of this pathway by Dcycloserine (DCS) is sufficient to further potentiate motor excitable in healthy humans.
Journal ArticleDOI
Increased Prefrontal Cortex Neurogranin Enhances Plasticity and Extinction Learning
Ling Zhong,Joshua C. Brown,Audra A. Kramer,Kanwardeep Kaleka,Amber Petersen,Jamie N. Krueger,Matthew A. Florence,Matthew J. Muelbl,Michelle Battle,Geoffrey G. Murphy,Christopher M. Olsen,Nashaat Z. Gerges +11 more
TL;DR: The results indicate that elevated neurogranin function within the PFC can enhance local plasticity and increase the rate of extinction learning across different behavioral tasks, and can provide a molecular link between enhanced Plasticity and enhanced extinction.