J
Joshua D. Podlevsky
Researcher at Arizona State University
Publications - 23
Citations - 1291
Joshua D. Podlevsky is an academic researcher from Arizona State University. The author has contributed to research in topics: Telomerase & Telomere. The author has an hindex of 14, co-authored 20 publications receiving 1057 citations. Previous affiliations of Joshua D. Podlevsky include Sandia National Laboratories & Max Planck Society.
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Journal ArticleDOI
The Telomerase Database
TL;DR: The Telomerase Database is a useful resource especially for researchers who are interested in investigating the structure, function, evolution and medical relevance of the telomerase enzyme.
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Low Cytotoxicity and Genotoxicity of Two-Dimensional MoS2 and WS2.
Jennie H. Appel,Duo O. Li,Joshua D. Podlevsky,Abhishek Debnath,Alexander A. Green,Qing Hua Wang,Junseok Chae +6 more
TL;DR: These findings demonstrate that neither mechanically exfoliated nor CVD-grown TMDs are deleterious to cellular viability or induce genetic defects, and these TMD’s appear biocompatible for future application in medical devices.
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Loss-of-function mutations in the RNA biogenesis factor NAF1 predispose to pulmonary fibrosis–emphysema
Susan E. Stanley,Dustin L. Gable,Christa L. Wagner,Thomas M. Carlile,Vidya Sagar Hanumanthu,Joshua D. Podlevsky,Sara E. Khalil,Amy E. DeZern,Maria F. Rojas-Duran,Carolyn D. Applegate,Jonathan K. Alder,Erin M. Parry,Wendy V. Gilbert,Mary Armanios +13 more
TL;DR: It is shown that NAF1 haploinsufficiency selectively disturbs telomere length homeostasis by decreasing the levels of telomerase RNA while sparing rRNA pseudouridylation, which is guided by snoRNAs and showed no evidence of ribosomal pathology.
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Telomerase mutations in smokers with severe emphysema.
Susan E. Stanley,Julian J.-L. Chen,Joshua D. Podlevsky,Jonathan K. Alder,Nadia N. Hansel,Rasika A. Mathias,Xiaodong Qi,Nicholas Rafaels,Robert A. Wise,Edwin K. Silverman,Kathleen C. Barnes,Mary Armanios +11 more
TL;DR: These findings identify germline mutations in telomerase as a Mendelian risk factor for COPD susceptibility that clusters in autosomal dominant families with telomere-mediated disease including pulmonary fibrosis.
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It all comes together at the ends: Telomerase structure, function, and biogenesis
TL;DR: The molecular mechanism of telomerase function has significance for the development of therapies for telomere-mediated disorders and cancer, and the techniques for assessing telomersase dysfunction are reviewed.