J
Joshua Rhein
Researcher at University of Minnesota
Publications - 113
Citations - 3210
Joshua Rhein is an academic researcher from University of Minnesota. The author has contributed to research in topics: Meningitis & Medicine. The author has an hindex of 23, co-authored 97 publications receiving 2420 citations. Previous affiliations of Joshua Rhein include Makerere University & University of Kansas.
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Journal ArticleDOI
Timing of antiretroviral therapy after diagnosis of cryptococcal meningitis
David R. Boulware,David B. Meya,David B. Meya,Conrad Muzoora,Melissa A. Rolfes,Katherine Huppler Hullsiek,Abdu K Musubire,Kabanda Taseera,Henry W. Nabeta,Charlotte Schutz,Darlisha A. Williams,Darlisha A. Williams,Radha Rajasingham,Joshua Rhein,Friedrich Thienemann,Melanie W. Lo,Melanie W. Lo,Kirsten Nielsen,Tracy L. Bergemann,Andrew Kambugu,Yukari C. Manabe,Yukari C. Manabe,Edward N. Janoff,Edward N. Janoff,Paul R. Bohjanen,Graeme Meintjes,Graeme Meintjes +26 more
TL;DR: Deferring ART for 5 weeks after the diagnosis of cryptococcal meningitis was associated with significantly improved survival, as compared with initiating ART at 1 to 2 weeks, especially among patients with a paucity of white cells in cerebrospinal fluid.
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Outcomes of Cryptococcal Meningitis in Uganda Before and After the Availability of Highly Active Antiretroviral Therapy
Andrew Kambugu,David B. Meya,Joshua Rhein,Meagan O’Brien,Edward N. Janoff,Allan R. Ronald,Allan R. Ronald,Moses R. Kamya,Harriet Mayanja-Kizza,Merle A. Sande,Paul R. Bohjanen,David R. Boulware +11 more
TL;DR: Significant CM-associated mortality persists, despite the administration of amphotericin B and HIV therapy, because of the high mortality rate before receipt of HAART and because of immune reconstitution inflammatory syndrome-related complications after HAART initiation.
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Clinical features and serum biomarkers in HIV immune reconstitution inflammatory syndrome after cryptococcal meningitis: a prospective cohort study.
David R. Boulware,David B. Meya,David B. Meya,Tracy L. Bergemann,Darin L. Wiesner,Joshua Rhein,Abdu K Musubire,Sarah J. Lee,Andrew Kambugu,Andrew Kambugu,Edward N. Janoff,Paul R. Bohjanen +11 more
TL;DR: Clinical features in a prospective cohort with AIDS and recent cryptococcal meningitis after initiation of antiretroviral therapy are investigated to identify biomarkers for prediction and diagnosis of CM-IRIS (cryptococcal meninigitis-related immune reconstitution inflammatory syndrome).
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Diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculous meningitis in HIV-infected adults: a prospective cohort study.
Nathan C. Bahr,Nathan C. Bahr,Edwin Nuwagira,Emily E Evans,Fiona V Cresswell,Fiona V Cresswell,Philip V Bystrom,Adolf Byamukama,Sarah C Bridge,Sarah C Bridge,Ananta S Bangdiwala,David B. Meya,David B. Meya,Claudia M. Denkinger,Conrad Muzoora,David R. Boulware,Darlisha A. Williams,Kabanda Taseera,Dan Nyehangane,Mugisha Ivan,Patrick Orikiriza,Joshua Rhein,Katherine Huppler Hullsiek,Abdu K Musubire,Katelyn A Pastick,Pamela Nabeta,James Mwesigye,Radha Rajasingham +27 more
TL;DR: World Health Organization (WHO) recommends the use of Xpert Ultra as the initial diagnostic test for suspected tuberculous meningitis, following an evaluation of the diagnostic performance of the new Xpert MTB/RIF Ultra (Xpert Ultra).
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Increased Antifungal Drug Resistance in Clinical Isolates of Cryptococcus neoformans in Uganda
Kyle D. Smith,Beatrice Achan,Katherine Huppler Hullsiek,Tami R. McDonald,Laura H. Okagaki,Ali A. Alhadab,Andrew Akampurira,Joshua Rhein,David B. Meya,David B. Meya,David R. Boulware,Kirsten Nielsen +11 more
TL;DR: Examination of antifungal drug susceptibility in 198 clinical isolates collected from Kampala, Uganda, between 2010 and 2014 using the CLSI broth microdilution assay developed and validated an assay that could easily be implemented in a resource-limited setting, with similar susceptibility results.