K
Kirsten Nielsen
Researcher at University of Minnesota
Publications - 83
Citations - 6594
Kirsten Nielsen is an academic researcher from University of Minnesota. The author has contributed to research in topics: Cryptococcus neoformans & Virulence. The author has an hindex of 39, co-authored 76 publications receiving 5603 citations. Previous affiliations of Kirsten Nielsen include Duke University & Howard Hughes Medical Institute.
Papers
More filters
Journal ArticleDOI
Sexual Cycle of Cryptococcus neoformans var. grubii and Virulence of Congenic a and α Isolates
TL;DR: These studies highlight a role for sexual recombination in the evolution of a human fungal pathogen and provide a robust genetic platform to establish the molecular determinants of virulence.
Journal ArticleDOI
Timing of antiretroviral therapy after diagnosis of cryptococcal meningitis
David R. Boulware,David B. Meya,David B. Meya,Conrad Muzoora,Melissa A. Rolfes,Katherine Huppler Hullsiek,Abdu K Musubire,Kabanda Taseera,Henry W. Nabeta,Charlotte Schutz,Darlisha A. Williams,Darlisha A. Williams,Radha Rajasingham,Joshua Rhein,Friedrich Thienemann,Melanie W. Lo,Melanie W. Lo,Kirsten Nielsen,Tracy L. Bergemann,Andrew Kambugu,Yukari C. Manabe,Yukari C. Manabe,Edward N. Janoff,Edward N. Janoff,Paul R. Bohjanen,Graeme Meintjes,Graeme Meintjes +26 more
TL;DR: Deferring ART for 5 weeks after the diagnosis of cryptococcal meningitis was associated with significantly improved survival, as compared with initiating ART at 1 to 2 weeks, especially among patients with a paucity of white cells in cerebrospinal fluid.
Journal ArticleDOI
Analysis of the Genome and Transcriptome of Cryptococcus neoformans var. grubii Reveals Complex RNA Expression and Microevolution Leading to Virulence Attenuation
Guilhem Janbon,Kate L. Ormerod,Damien Paulet,Edmond J. Byrnes,Vikas Yadav,Gautam Chatterjee,Nandita Mullapudi,Chung-Chau Hon,R. Blake Billmyre,François Brunel,Yong Sun Bahn,Weidong Chen,Yuan Chen,Eve W. L. Chow,Jean Yves Coppée,Anna Floyd-Averette,Claude Gaillardin,Kimberly J. Gerik,Jonathan M. Goldberg,Sara Gonzalez-Hilarion,Sharvari Gujja,Joyce L. Hamlin,Yen-Ping Hsueh,Yen-Ping Hsueh,Giuseppe Ianiri,Steven J.M. Jones,Chinnappa D. Kodira,Lukasz Kozubowski,Woei Lam,Marco A. Marra,Larry D. Mesner,Piotr A. Mieczkowski,Frédérique Moyrand,Kirsten Nielsen,Kirsten Nielsen,Caroline Proux,Tristan Rossignol,Jacqueline E. Schein,Sheng Sun,Carolin Wollschlaeger,Ian A. Wood,Qiandong Zeng,Cécile Neuvéglise,Carol S. Newlon,John R. Perfect,Jennifer K. Lodge,Alexander Idnurm,Jason E. Stajich,Jason E. Stajich,James W. Kronstad,Kaustuv Sanyal,Joseph Heitman,James A. Fraser,Christina A. Cuomo,Fred S. Dietrich +54 more
TL;DR: The spectrum of mutations identified provides insights into the genetics underlying the micro-evolution of a laboratory strain, and identifies mutations involved in stress responses, mating efficiency, and virulence.
Journal ArticleDOI
Cryptococcus: from environmental saprophyte to global pathogen.
TL;DR: Recent discoveries that illustrate the intricacy of host–pathogen interactions and reveal new details about the host immune responses that either help to protect against disease or increase host susceptibility are described.
Journal ArticleDOI
Deciphering the model pathogenic fungus Cryptococcus neoformans.
TL;DR: The biology of C. neoformans is discussed in light of this genomic data, with a special emphasis on the role that evolution and sexual reproduction have in the complex relationships of the fungus with the environment and the host.