D
Darin L. Wiesner
Researcher at University of Wisconsin-Madison
Publications - 34
Citations - 2124
Darin L. Wiesner is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Immune system & Cryptococcus neoformans. The author has an hindex of 16, co-authored 29 publications receiving 1673 citations. Previous affiliations of Darin L. Wiesner include University of Minnesota.
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Journal ArticleDOI
Cryptococcus: from environmental saprophyte to global pathogen.
TL;DR: Recent discoveries that illustrate the intricacy of host–pathogen interactions and reveal new details about the host immune responses that either help to protect against disease or increase host susceptibility are described.
Journal ArticleDOI
Pulmonary neuroendocrine cells amplify allergic asthma responses
Pengfei Sui,Pengfei Sui,Darin L. Wiesner,Jinhao Xu,Jinhao Xu,Yan Zhang,Yan Zhang,Jinwoo Lee,Steven J. Van Dyken,Amber J. Lashua,Chuyue Yu,Bruce S. Klein,Richard M. Locksley,Gail H. Deutsch,Xin Sun,Xin Sun +15 more
TL;DR: In vitro data show that pulmonary neuroendocrine cells (PNECs), a rare airway epithelial cell population, can act as chemosensors, and the underlying mechanisms by identifying molecular effectors and cellular targets of PNECs are elucidated.
Journal ArticleDOI
Clinical features and serum biomarkers in HIV immune reconstitution inflammatory syndrome after cryptococcal meningitis: a prospective cohort study.
David R. Boulware,David B. Meya,David B. Meya,Tracy L. Bergemann,Darin L. Wiesner,Joshua Rhein,Abdu K Musubire,Sarah J. Lee,Andrew Kambugu,Andrew Kambugu,Edward N. Janoff,Paul R. Bohjanen +11 more
TL;DR: Clinical features in a prospective cohort with AIDS and recent cryptococcal meningitis after initiation of antiretroviral therapy are investigated to identify biomarkers for prediction and diagnosis of CM-IRIS (cryptococcal meninigitis-related immune reconstitution inflammatory syndrome).
Journal ArticleDOI
Chitin recognition via chitotriosidase promotes pathologic type-2 helper T cell responses to cryptococcal infection.
Darin L. Wiesner,Charles A. Specht,Chrono K. Lee,Kyle D. Smith,Liliane Mukaremera,S. Thera Lee,Chun Geun Lee,Jack A. Elias,Judith N. Nielsen,David R. Boulware,Paul R. Bohjanen,Marc K. Jenkins,Stuart M. Levitz,Kirsten Nielsen +13 more
TL;DR: A peptide-MHCII tetramer was developed to track antigen-specific CD4+ T cells produced in response to infection with the fungal pathogen Cryptococcus neoformans, and it was found that chitin abundance impacted Th2 cell accumulation and disease.
Journal ArticleDOI
Paucity of initial cerebrospinal fluid inflammation in cryptococcal meningitis is associated with subsequent immune reconstitution inflammatory syndrome
David R. Boulware,Shulamith C. Bonham,David B. Meya,Darin L. Wiesner,Gregory S. Park,Andrew Kambugu,Edward N. Janoff,Paul R. Bohjanen +7 more
TL;DR: Patients who subsequently develop CM-related IRIS exhibit less initial CSF inflammation at the time of CM diagnosis, compared with those who do not develop IRIS, and the inflammatory CSF cytokine profiles observed at time of IRIS can distinguish IRIS from CM relapse.