K
Katherine Huppler Hullsiek
Researcher at University of Minnesota
Publications - 105
Citations - 5985
Katherine Huppler Hullsiek is an academic researcher from University of Minnesota. The author has contributed to research in topics: Meningitis & Population. The author has an hindex of 40, co-authored 93 publications receiving 5214 citations. Previous affiliations of Katherine Huppler Hullsiek include Uniformed Services University of the Health Sciences & Naval Medical Center San Diego.
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Journal ArticleDOI
Hydroxychloroquine in Nonhospitalized Adults With Early COVID-19 : A Randomized Trial.
Caleb P Skipper,Katelyn A Pastick,Nicole S Engen,Ananta S Bangdiwala,Mahsa Abassi,Sarah M Lofgren,Darlisha A. Williams,Elizabeth C Okafor,Matthew F Pullen,Melanie R. Nicol,Alanna A Nascene,Katherine Huppler Hullsiek,Matthew P. Cheng,Darlette Luke,Sylvain A. Lother,Lauren J. MacKenzie,Glen Drobot,Lauren E. Kelly,Ilan S. Schwartz,Ryan Zarychanski,Emily G. McDonald,Todd C. Lee,Radha Rajasingham,David R. Boulware +23 more
TL;DR: This randomized, double-blind, placebo-controlled trial evaluated effects of oral hydroxychloroquine on symptoms and disease severity in adult outpatients with early COVID-19.
Journal ArticleDOI
Low-abundance drug-resistant viral variants in chronically HIV-infected, antiretroviral treatment-naive patients significantly impact treatment outcomes.
Birgitte B. Simen,Jan Fredrik Simons,Katherine Huppler Hullsiek,Richard M. Novak,Rodger D. MacArthur,John D. Baxter,Chunli Huang,Christine Lubeski,Gregory S. Turenchalk,Michael S. Braverman,Brian Desany,Jonathan M. Rothberg,Michael Egholm,Michael J. Kozal +13 more
TL;DR: Ultra-deep sequencing identified a significantly larger proportion of HIV-infected, treatment-naive persons as harboring drug-resistant viral variants.
Journal ArticleDOI
Timing of antiretroviral therapy after diagnosis of cryptococcal meningitis
David R. Boulware,David B. Meya,David B. Meya,Conrad Muzoora,Melissa A. Rolfes,Katherine Huppler Hullsiek,Abdu K Musubire,Kabanda Taseera,Henry W. Nabeta,Charlotte Schutz,Darlisha A. Williams,Darlisha A. Williams,Radha Rajasingham,Joshua Rhein,Friedrich Thienemann,Melanie W. Lo,Melanie W. Lo,Kirsten Nielsen,Tracy L. Bergemann,Andrew Kambugu,Yukari C. Manabe,Yukari C. Manabe,Edward N. Janoff,Edward N. Janoff,Paul R. Bohjanen,Graeme Meintjes,Graeme Meintjes +26 more
TL;DR: Deferring ART for 5 weeks after the diagnosis of cryptococcal meningitis was associated with significantly improved survival, as compared with initiating ART at 1 to 2 weeks, especially among patients with a paucity of white cells in cerebrospinal fluid.
Journal ArticleDOI
Low-frequency HIV-1 drug resistance mutations and risk of NNRTI-based antiretroviral treatment failure: a systematic review and pooled analysis
Jonathan Z. Li,Roger Paredes,Heather J. Ribaudo,Evguenia S. Svarovskaia,Karin J. Metzner,Michael J. Kozal,Katherine Huppler Hullsiek,Melanie Balduin,Martin R. Jakobsen,Anna Maria Geretti,Rodolphe Thiébaut,Lars Østergaard,Bernard Masquelier,Jeffrey A. Johnson,Michael D. Miller,Daniel R. Kuritzkes +15 more
TL;DR: In a pooled analysis, low-frequency HIV-1 drug resistance mutations, particularly involving NNRTI resistance, were significantly associated with a dose-dependent increased risk of virologic failure with first-line ART.
Journal ArticleDOI
Higher levels of CRP, D-dimer, IL-6, and hyaluronic acid before initiation of antiretroviral therapy (ART) are associated with increased risk of AIDS or death
David R. Boulware,Katherine Huppler Hullsiek,Camille E. Puronen,Adam Rupert,Jason V. Baker,Jason V. Baker,Martyn A. French,Paul R. Bohjanen,Richard M. Novak,James D. Neaton,Irini Sereti +10 more
TL;DR: Biomarkers of Inflammation (CRP, IL-6), coagulation (D-dimer), and tissue fibrosis (HA) measured pre-ART and at 1 month are associated with higher risk of AIDS events, IRIS, or death, warranting additional study as risk stratification strategies.