J
Joshua Spurrier
Researcher at National Institutes of Health
Publications - 14
Citations - 244
Joshua Spurrier is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Gene & Medicine. The author has an hindex of 7, co-authored 9 publications receiving 172 citations.
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Journal ArticleDOI
Enhanced protein expression in the baculovirus/insect cell system using engineered SUMO fusions
TL;DR: The SUMOstar system will make significant impact in difficult-to-express proteins and especially to those proteins that require the native N-terminal residue for function.
Journal ArticleDOI
Hyperactive Innate Immunity Causes Degeneration of Dopamine Neurons upon Altering Activity of Cdk5
TL;DR: A molecular pathway that links innate immunity to age-dependent loss of dopaminergic neurons in Drosophila is identified and it is found that altering the expression of the activating subunit of the Cdk5 protein kinase causes severe disruption of autophagy.
Journal ArticleDOI
Molecular and cellular evolution of the primate dorsolateral prefrontal cortex
Shaojie Ma,Mario Skarica,Qian Li,Chuan Xu,Ryan D. Risgaard,Andrew T.N. Tebbenkamp,Xoel Mato-Blanco,Rothem Kovner,Željka Krsnik,Xabier de Martin,Victor Luria,Xavier Martí-Pérez,Dandan Liang,Amir Karger,Danielle K Schmidt,Zachary Gomez-Sanchez,Cai Qi,Kevin T Gobeske,Sirisha Pochareddy,Ashwin Debnath,Cade J Hottman,Joshua Spurrier,Leon Teo,Anthony G. Boghdadi,Jihane Homman-Ludiye,John J. Ely,Etienne W. Daadi,Da Mi,Marcel M. Daadi,Oscar Marín,Patrick R. Hof,Mladen-Roko Rasin,James A. Bourne,Chet C. Sherwood,Gabriel Santpere,Matthew J. Girgenti,Stephen M. Strittmatter,André M. M. Sousa,Nenad Sestan +38 more
TL;DR: A comprehensive survey of dlPFC cellular repertoire and its shared and divergent features in anthropoid primates is generated and several transcriptomically-defined cell subtypes are conserved.
Metastatic Adenocarcinoma Cell Lines with Multipotent Progenitor Activity
Wassim Abou-Kheir,Paul G. Hynes,Philip Martin,Juan Juan Yin,Yen-Nien Liu,Victoria Seng,Ross Lake,Joshua Spurrier,Kathleen Kelly +8 more
TL;DR: The in vitro creation of a mouse cell line, selected for growth as self-renewing stem/progenitor cells, which manifests many in vivo properties of aggressive prostate cancer suggests that transformed prostate progenitor cells preferentially differentiate toward luminal cells and recapitulate many characteristics of the human disease.
Journal ArticleDOI
Self-renewing Pten-/- TP53-/- protospheres produce metastatic adenocarcinoma cell lines with multipotent progenitor activity.
Wassim Abou-Kheir,Wassim Abou-Kheir,Paul G. Hynes,Philip Martin,Juan Juan Yin,Yen Nien Liu,Victoria Seng,Ross Lake,Joshua Spurrier,Kathleen Kelly +9 more
TL;DR: In this paper, a mouse cell line, selected for growth as self-renewing stem/progenitor cells, which manifests many in vivo properties of aggressive prostate cancer was created.