R
Ryan D. Risgaard
Researcher at University of Wisconsin-Madison
Publications - 7
Citations - 83
Ryan D. Risgaard is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 2, co-authored 2 publications receiving 21 citations.
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Journal ArticleDOI
Identification of FMR1-regulated molecular networks in human neurodevelopment
Meng Li,Junha Shin,Ryan D. Risgaard,Molly J. Parries,Jianyi Wang,Deborah Chasman,Shuang Liu,Sushmita Roy,Anita Bhattacharyya,Xinyu Zhao +9 more
TL;DR: A modified CLIP-seq strategy is applied to identify genome-wide targets of the FMRP translational regulator 1 (FMR1), a brain-enriched RNA-BP whose deficiency leads to Fragile X Syndrome (FXS), the most prevalent inherited intellectual disability.
Journal ArticleDOI
Molecular and cellular evolution of the primate dorsolateral prefrontal cortex
Shaojie Ma,Mario Skarica,Qian Li,Chuan Xu,Ryan D. Risgaard,Andrew T.N. Tebbenkamp,Xoel Mato-Blanco,Rothem Kovner,Željka Krsnik,Xabier de Martin,Victor Luria,Xavier Martí-Pérez,Dandan Liang,Amir Karger,Danielle K Schmidt,Zachary Gomez-Sanchez,Cai Qi,Kevin T Gobeske,Sirisha Pochareddy,Ashwin Debnath,Cade J Hottman,Joshua Spurrier,Leon Teo,Anthony G. Boghdadi,Jihane Homman-Ludiye,John J. Ely,Etienne W. Daadi,Da Mi,Marcel M. Daadi,Oscar Marín,Patrick R. Hof,Mladen-Roko Rasin,James A. Bourne,Chet C. Sherwood,Gabriel Santpere,Matthew J. Girgenti,Stephen M. Strittmatter,André M. M. Sousa,Nenad Sestan +38 more
TL;DR: A comprehensive survey of dlPFC cellular repertoire and its shared and divergent features in anthropoid primates is generated and several transcriptomically-defined cell subtypes are conserved.
Journal ArticleDOI
Astroglial FMRP deficiency cell-autonomously up-regulates miR-128 and disrupts developmental astroglial mGluR5 signaling.
TL;DR: An FMRP-dependent cell-autonomous miR pathway that alters developmental astroglial mGluR5 signaling, which unveils astroglia-specific molecular mechanisms involved in FXS pathogenesis is defined.
Journal ArticleDOI
BOMA, a machine-learning framework for comparative gene expression analysis across brains and organoids
Ch. He,Noah Cohen Kalafut,Soraya O. Sandoval,Ryan D. Risgaard,Chenxi Yang,Saniya Khullar,Marin Suzuki,Qiang Chang,Xinyu Zhao,André M. M. Sousa,Daifeng Wang +10 more
TL;DR: In this paper , a machine learning framework, brain and organoid manifold alignment (BOMA), is proposed to perform global alignment of developmental gene expression data between brains and organoids.
Posted ContentDOI
Autofluorescence is a biomarker of neural stem cell activation state
Christopher S. Morrow,Kelsey Tweed,Zachary P. Arndt,Alex J. Walsh,Bo Peng,Ryan D. Risgaard,Payton Klosa,Michelle M. Chi,Eli Wallace,Avtar Roopra,Melissa C. Skala,Darcie L. Moore +11 more
TL;DR: In this paper , autofluorescence was used to discriminate neural stem cells (NSCs) activation state and to predict cell behavior and track the dynamics of quiescence exit at single cell resolution in vitro and in vivo.