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Andrew T.N. Tebbenkamp
Researcher at Yale University
Publications - 20
Citations - 2145
Andrew T.N. Tebbenkamp is an academic researcher from Yale University. The author has contributed to research in topics: Huntingtin & Genetically modified mouse. The author has an hindex of 14, co-authored 19 publications receiving 1685 citations. Previous affiliations of Andrew T.N. Tebbenkamp include University of Florida & McKnight Brain Institute.
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Journal ArticleDOI
Coexpression Networks Implicate Human Midfetal Deep Cortical Projection Neurons in the Pathogenesis of Autism
A. Jeremy Willsey,A. Jeremy Willsey,Stephen Sanders,Stephen Sanders,Mingfeng Li,Shan Dong,Shan Dong,Andrew T.N. Tebbenkamp,Rebecca A. Muhle,Steven K. Reilly,Leon Lin,Sofia Fertuzinhos,Jeremy A. Miller,Michael T. Murtha,Candace Bichsel,Wei Niu,Justin Cotney,A. Gulhan Ercan-Sencicek,Jake Gockley,Abha R. Gupta,Wenqi Han,Xin He,Ellen J. Hoffman,Lambertus Klei,Jing Lei,Wenzhong Liu,Li Liu,Cong Lu,Xuming Xu,Ying Zhu,Shrikant Mane,Ed S. Lein,Liping Wei,James P. Noonan,Kathryn Roeder,Bernie Devlin,Nenad Sestan,Matthew W. State +37 more
TL;DR: Coexpression networks are constructed based on the hcASD "seed" genes, leveraging a rich expression data set encompassing multiple human brain regions across human development and into adulthood and demonstrate a key point of convergence in midfetal layer 5/6 cortical projection neurons.
Journal ArticleDOI
The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment
Justin Cotney,Rebecca A. Muhle,Stephen Sanders,Stephen Sanders,Li Liu,A. Jeremy Willsey,A. Jeremy Willsey,Wei Niu,Wenzhong Liu,Lambertus Klei,Jing Lei,Jun Yin,Steven K. Reilly,Andrew T.N. Tebbenkamp,Candace Bichsel,Mihovil Pletikos,Nenad Sestan,Kathryn Roeder,Matthew W. State,Bernie Devlin,James P. Noonan +20 more
TL;DR: This work identifies genes targeted by CHD8, a chromodomain helicase strongly associated with ASD, in human midfetal brain, human neural stem cells (hNSCs) and embryonic mouse cortex, and suggests loss of CHD 8 contributes to ASD by perturbing an ancient gene regulatory network during human brain development.
Journal ArticleDOI
Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia
Marco Onorati,Zhen Li,Fuchen Liu,André M. M. Sousa,Naoki Nakagawa,Mingfeng Li,Maria Teresa Dell’Anno,Forrest O. Gulden,Sirisha Pochareddy,Andrew T.N. Tebbenkamp,Wenqi Han,Mihovil Pletikos,Tianliuyun Gao,Ying Zhu,Candace Bichsel,Luis Varela,Klara Szigeti-Buck,Steven Lisgo,Yalan Zhang,Anze Testen,Xiao-Bing Gao,Jernej Mlakar,Mara Popović,Marie Flamand,Stephen M. Strittmatter,Leonard K. Kaczmarek,Eva S. Anton,Tamas L. Horvath,Brett D. Lindenbach,Nenad Sestan +29 more
TL;DR: It is shown that ZIKV infects both neocortical and spinal cord neuroepithelial stem cells as well as their fetal homolog, radial glial cells (RGCs), causing disrupted mitoses, supernumerary centrosomes, structural disorganization, and cell death.
Journal ArticleDOI
Molecular and cellular reorganization of neural circuits in the human lineage
André M. M. Sousa,Ying Zhu,Mary Ann Raghanti,Robert R. Kitchen,Marco Onorati,Marco Onorati,Andrew T.N. Tebbenkamp,Bernardo Stutz,Kyle A. Meyer,Mingfeng Li,Yuka Imamura Kawasawa,Yuka Imamura Kawasawa,Fuchen Liu,Raquel Garcia Perez,Marta Melé,Tiago Carvalho,Mario Skarica,Forrest O. Gulden,Mihovil Pletikos,Akemi Shibata,Alexa R. Stephenson,Melissa K. Edler,John J. Ely,John D. Elsworth,Tamas L. Horvath,Patrick R. Hof,Thomas M. Hyde,Joel E. Kleinman,Daniel R. Weinberger,Mark Reimers,Richard P. Lifton,Richard P. Lifton,Richard P. Lifton,Shrikant Mane,James P. Noonan,Matthew W. State,Ed S. Lein,James A. Knowles,Tomas Marques-Bonet,Tomas Marques-Bonet,Chet C. Sherwood,Mark Gerstein,Nenad Sestan +42 more
TL;DR: Comparing transcriptome and histology of human and nonhuman primate brains reveals changes that make humans unique, and diverse molecular and cellular features of the phylogenetic reorganization of the human brain across multiple levels, with relevance for brain function and disease.
Journal ArticleDOI
The Developmental Transcriptome of the Human Brain: Implications for Neurodevelopmental Disorders
TL;DR: In this paper, a comprehensive review of the transcriptome of the developing human brain is presented, focusing on coding and non-coding RNAs that will be instrumental for illuminating the underlying biology of complex neurodevelopmental disorders.