J
JS Wyatt
Researcher at University College London
Publications - 136
Citations - 12351
JS Wyatt is an academic researcher from University College London. The author has contributed to research in topics: Cerebral blood flow & Cerebral oxygen saturation. The author has an hindex of 53, co-authored 136 publications receiving 11891 citations. Previous affiliations of JS Wyatt include University of Essex.
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Journal ArticleDOI
Estimation of optical pathlength through tissue from direct time of flight measurement
TL;DR: Monte Carlo modelling of light pulses in tissue has shown that the mean value of the time dispersed light pulse correlates with the pathlength used in quantitative spectroscopic calculations, and this result has been verified in a phantom material.
Journal ArticleDOI
Characterization of the near infrared absorption spectra of cytochrome aa3 and haemoglobin for the non-invasive monitoring of cerebral oxygenation.
TL;DR: The cytochrome aa3 spectrum in vivo from the brains of rats after replacing the blood with a fluorocarbon substitute is obtained and an algorithm for calculating the changes in oxygenated and deoxygenated haemoglobin and oxygenated cy tochrome a a3 in tissue from changes in near IR absorption is constructed.
Journal ArticleDOI
Quantification of cerebral oxygenation and haemodynamics in sick newborn infants by near infrared spectrophotometry.
TL;DR: NIR spectrophotometry provides valuable quantitative data at the cotside for the management of sick infants and for exploring the pathophysiology of damage to the brain.
Journal ArticleDOI
Delayed ("secondary") cerebral energy failure after acute hypoxia-ischemia in the newborn piglet: Continuous 48-hour studies by phosphorus magnetic resonance spectroscopy
A Lorek,Y Takei,EB Cady,JS Wyatt,Juliet Penrice,A D Edwards,D Peebles,Marzena Wylezinska,H Owen-Reece,Vincent Kirkbride,Chris E. Cooper,RF Aldridge,Simon Roth,Guy C. Brown,D. T. Delpy,E O R Reynolds +15 more
TL;DR: The severity of secondary energy failure, as judged by the lowest [PCr/[Pi] recorded at 24-48 h, was directly related to the extent of acute energy depletion, obtained as the time integral of reduction in [NTP]/[EPP] (p<0.0001).
Book ChapterDOI
Methods of Quantitating Cerebral Near Infrared Spectroscopy Data
TL;DR: Non invasive infrared spectroscopy is a well established technique for monitoring changes in the oxygenation status of tissues by observing the absorption of haemoglobin and cytochrome aa3 respectively and it has normally not been possible to quantitate the observed changes.