Juan Antonio Moreno

TL;DR: Under most test conditions, specific NF-kappaB inhibitors tend to reduce inflammation in experimental kidney injury but not always, and although many drugs in current use clinically influence NF- kappaB activation, there are no data regarding specificNF-kappB inhibition in human kidney disease.

TL;DR: Inflammatory cytokines, such as TWEAK and TNFα, downregulate Klotho expression through an NFκB-dependent mechanism, which may partially explain the relationship between inflammation and diseases characterized by accelerated aging of organs, including CKD.

TL;DR: A meal containing high-phenolic virgin olive oil improves ischemic reactive hyperemia during the postprandial state, and this phenomenon might be mediated via reduction in oxidative stress and the increase of nitric oxide metabolites.

TL;DR: The results suggest that TWEAK-CD163 interaction takes place in vivo, probably decreasing TWEak plasma concentration and that CD163-TWEAK plasma ratio is a potential biomarker of clinical and subclinical atherosclerosis.

TL;DR: This review examines the recent preclinical and clinical research about the potentially harmful effects of lipid effects in the kidney, metabolic markers associated with these mechanisms, major signaling pathways affected, the causes of excessive lipid accumulation, and the types of lipids involved, as well as offers a comprehensive update of therapeutic strategies targeting lipotoxicity.