J
Juan José Cazzulo
Researcher at National University of General San Martín
Publications - 113
Citations - 4892
Juan José Cazzulo is an academic researcher from National University of General San Martín. The author has contributed to research in topics: Trypanosoma cruzi & Cruzipain. The author has an hindex of 42, co-authored 113 publications receiving 4700 citations. Previous affiliations of Juan José Cazzulo include Facultad de Ciencias Exactas y Naturales.
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Aerobic fermentation of glucose by trypanosomatids.
TL;DR: The consumption of glucose by trypanosomatid protozoa is characterized by the excretion of reduced products such as succinate, pyruvate, ethanol, l‐alanine, or lactate not only in anaerobiosis, but also under aerobic conditions.
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End products and enzyme levels of aerobic glucose fermentation in trypanosomatids.
TL;DR: The results are in good agreement with current ideas on the mechanism of aerobic glucose fermentation by trypanosomatids, and suggest that, under the experimental conditions used, both T. cruzi and C. fasciculata used glucose perferentially over amino acids for growth.
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The major cysteine proteinase (cruzipain) from Trypanosoma cruzi is encoded by multiple polymorphic tandemly organized genes located on different chromosomes.
TL;DR: It is demonstrated that cruzipain, the major cysteine proteinase of Trypanosoma cruzi epimastigotes, is encoded by a large number of tandemly arranged genes, and the sequence is conserved among the repeat units, although polymorphisms clearly exist.
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The major cysteine proteinase of Trypanosoma cruzi: a valid target for chemotherapy of Chagas disease.
TL;DR: The curative effects observed, as well as the good bioavailability of the inhibitor and its apparent lack of undesirable side effects, make it a promising lead compound for the development of new drugs for the chemotherapy of Chagas disease.
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Autophagy is involved in nutritional stress response and differentiation in Trypanosoma cruzi.
TL;DR: Autophagy is involved in differentiation between developmental stages of T. cruzi, a process that is essential for parasite maintenance and survival, suggesting that the autophagy pathway could represent a target for a novel chemotherapeutic strategy against Chagas disease.