J
Juan-Jose Ventura
Researcher at Katholieke Universiteit Leuven
Publications - 31
Citations - 2954
Juan-Jose Ventura is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Kinase & Stem cell. The author has an hindex of 21, co-authored 31 publications receiving 2826 citations. Previous affiliations of Juan-Jose Ventura include University of Massachusetts Medical School & University of Cambridge.
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Journal ArticleDOI
Mechanism of p38 MAP kinase activation in vivo
Deborah Marie Brancho,Nobuyuki Tanaka,Anja Jaeschke,Juan-Jose Ventura,Nyaya Kelkar,Yoshinori Tanaka,Masanao Kyuuma,Toshikazu Takeshita,Richard A. Flavell,Roger J. Davis +9 more
TL;DR: It is shown that MKK3 and MKK6 are essential for tumor necrosis factor-stimulated p38 MAPK activation, and loss of p38MAPK activation in the mutant cells was associated with defects in growth arrest and increased tumorigenesis.
Journal ArticleDOI
Chemical Genetic Analysis of the Time Course of Signal Transduction by JNK
Juan-Jose Ventura,Anette Hübner,Chao Zhang,Richard A. Flavell,Kevan M. Shokat,Roger J. Davis +5 more
TL;DR: It is reported that both the early and late phases of JNK activation contribute to TNF-induced gene expression, and the time course of J NK signaling can influence the biological response to JNKactivation.
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JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species
TL;DR: Data indicate that JNK can shift the balance of TNF-stimulated cell death from apoptosis to necrosis, which may represent a contributing factor in stress-induced inflammatory responses mediated by JNK.
Journal ArticleDOI
p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation.
Juan-Jose Ventura,Stephan Tenbaum,Eusebio Perdiguero,Marion Huth,Carmen Guerra,Mariano Barbacid,Manolis Pasparakis,Manolis Pasparakis,Angel R. Nebreda +8 more
TL;DR: The results indicate that by coordinating proliferation and differentiation signals in lung stem and progenitor cells, p38α has a key role in the regulation of lung cell renewal and tumorigenesis.
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JunD mediates survival signaling by the JNK signal transduction pathway.
TL;DR: It is demonstrated that JNK-stimulated survival signaling can be mediated by JunD, and the JNK/JunD pathway can collaborate with NF-kappaB to increase antiapoptotic gene expression.