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Nobuyuki Tanaka
Researcher at Keio University
Publications - 515
Citations - 13134
Nobuyuki Tanaka is an academic researcher from Keio University. The author has contributed to research in topics: Medicine & Dropping mercury electrode. The author has an hindex of 46, co-authored 470 publications receiving 11729 citations. Previous affiliations of Nobuyuki Tanaka include Tohoku University & Karolinska Institutet.
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Journal ArticleDOI
Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
Eri H. Kobayashi,Takafumi Suzuki,Ryo Funayama,Takeshi Nagashima,Makiko Hayashi,Hiroki Sekine,Nobuyuki Tanaka,Takashi Moriguchi,Hozumi Motohashi,Keiko Nakayama,Masayuki Yamamoto +10 more
TL;DR: It is demonstrated that Nrf2 interferes with lipopolysaccharide-induced transcriptional upregulation of proinflammatory cytokines, including IL-6 and IL-1β, and establishes a molecular basis for an NRF2-mediated anti-inflammation approach.
Journal ArticleDOI
Cloning of the gamma chain of the human IL-2 receptor
Toshikazu Takeshita,Hironobu Asao,Kiyoshi Ohtani,Naoto Ishii,Satoru Kumaki,Nobuyuki Tanaka,Hiroshi Munakata,Masataka Nakamura,Kazuo Sugamura +8 more
TL;DR: A third subunit, the gamma chain, of the human interleukin-2 receptor (IL-2R) was identified, and a complementary DNA clone encoding this member of the cytokine receptor family was isolated.
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TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
Jae-Hyuck Shim,Changchun Xiao,Amber E. Paschal,Shannon T. Bailey,Ping Rao,Matthew S. Hayden,Ki-Young Lee,Crystal Bussey,Michael Steckel,Nobuyuki Tanaka,Gen Yamada,Shizuo Akira,Kunihiro Matsumoto,Sankar Ghosh +13 more
TL;DR: The studies suggests that TAK1 acts as an upstream activating kinase for IKKbeta and JNK, but not IKKalpha, revealing an unexpectedly specific role of TAK 1 in inflammatory signaling pathways.
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Mechanism of p38 MAP kinase activation in vivo
Deborah Marie Brancho,Nobuyuki Tanaka,Anja Jaeschke,Juan-Jose Ventura,Nyaya Kelkar,Yoshinori Tanaka,Masanao Kyuuma,Toshikazu Takeshita,Richard A. Flavell,Roger J. Davis +9 more
TL;DR: It is shown that MKK3 and MKK6 are essential for tumor necrosis factor-stimulated p38 MAPK activation, and loss of p38MAPK activation in the mutant cells was associated with defects in growth arrest and increased tumorigenesis.
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The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID.
Kazuo Sugamura,Hironobu Asao,Motonari Kondo,Nobuyuki Tanaka,Naoto Ishii,Kazuyuki Ohbo,Masataka Nakamura,Toshikazu Takeshita +7 more
TL;DR: The molecular identification of the gamma chain brought a grasp of the structures and functions of the cytokine receptor and an in-depth understanding of the cause of human XSCID.