Juan Orduna

TL;DR: Evidence that AMPK is activated in authentic hypoxic tumor microenvironments is obtained and that this activity overlaps with regions of hypoxia detected by a chemical probe, which implies that HIF-1 and AMPK are components of a concerted cellular response to maintain energy homeostasis in low-oxygen or ischemic-tissue microen environments.

TL;DR: In this paper, the authors conducted an in vivo magnetic resonance imaging and spectroscopy study to test the hypothesis that binge EtOH exposure would injure but not cause the death of neurons as previously ascertained postmortem.

TL;DR: Novel in vivo evidence is provided for alcohol exposure as causing changes in brain chemistry in the absence of protracted withdrawal, pronounced thiamine deficiency, or severe liver damage, as demonstrated in sibling pairs of wild-type Wistar rats.

TL;DR: The mixed NOP/μ-opioid partial agonist SR 16435 exhibited both NOP and μ-OPioid receptor-mediated behaviors, indicating that both opioid and NOP receptors mediate this behavior.

TL;DR: Results indicate that, in mice, circuitry mediating antinociceptive activity in acute and chronic pain states is different, and that supraspinal up-regulation could lead to an attenuation of morphine ant inociception and antiallodynia, which can be alleviated by an NOP receptor antagonist.