Khalid Amin

TL;DR: Evidence that AMPK is activated in authentic hypoxic tumor microenvironments is obtained and that this activity overlaps with regions of hypoxia detected by a chemical probe, which implies that HIF-1 and AMPK are components of a concerted cellular response to maintain energy homeostasis in low-oxygen or ischemic-tissue microen environments.

TL;DR: Experiments revealed that the rapid cardioprotective effect of EPO during ischemia‐reperfusion injury was associated with preservation of ATP levels in the ischemic myocardium.

TL;DR: A novel function for EPO is demonstrated by providing in vivo evidence for a physiological role during fibrin-induced wound healing and correlated with changes in levels of inducible nitric oxide synthase protein in granulation tissue.

TL;DR: Local, one-time administration of a neutralizing anti-EPO antibody, soluble EPO receptor, or an inhibitor of Jak2 resulted in a delay in tumor growth with 45% reduction in maximal tumor depth in tumor Z-chamber model in a dose-dependent manner.

TL;DR: A novel class of indole analogs were used to optimize I3C's anticancer actions, including blocking growth factor-stimulated Akt activation and exhibited potent oral anticancer activity against various cancers and no significant toxicity.