Juanito J. Meneses

TL;DR: It is found that EGF-R-/- mice survive for up to 8 days after birth and suffer from impaired epithelial development in several organs, including skin, lung and gastrointestinal tract.

TL;DR: While individual cells in the epiblast sheet behave independently with respect to their neighbours, morphogenetic movement during germ layer formation is coordinated in the population as a whole and indicates that, despite geometrical differences, topological fate relationships are conserved among these vertebrates.

TL;DR: It is proposed that Nkx2.2 is required for the final differentiation of pancreatic beta cells, and in its absence, beta cells are trapped in an incompletely differentiated state.

TL;DR: In vitro analysis showed that trophoblast function in beta 1-null peri-implantation embryos was largely normal, including expression of tissue-specific markers, and outgrowth on fibronectin- and vitronECTin-coated, although not on laminin- coated substrates, which suggests beta 1 integrins are required for normal morphogenesis of the inner cell mass.

TL;DR: It is reported that mice lacking both DlX-1 and Dlx-2 have a time-dependent block in striatal differentiation, which indicates abnormalities in the development of the striatal subventricular zone and in the differentiation of striatal matrix neurons.