D
Dennis J. Hartigan-O'Connor
Researcher at University of California, Davis
Publications - 66
Citations - 3987
Dennis J. Hartigan-O'Connor is an academic researcher from University of California, Davis. The author has contributed to research in topics: Immune system & Medicine. The author has an hindex of 23, co-authored 55 publications receiving 3469 citations. Previous affiliations of Dennis J. Hartigan-O'Connor include California National Primate Research Center & University of California, San Francisco.
Papers
More filters
Journal ArticleDOI
Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signalling
James Briscoe,Lori Sussel,Palle Serup,Dennis J. Hartigan-O'Connor,Thomas M. Jessell,John L.R. Rubenstein,Johan Ericson +6 more
TL;DR: Evidence is provided that Nkx2.2 has a primary role in ventral neuronal patterning and has an essential role in interpreting graded Shh signals and selecting neuronal identity.
Journal ArticleDOI
Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells
Lori Sussel,J. Kalamaras,Dennis J. Hartigan-O'Connor,Juanito J. Meneses,Roger A. Pedersen,John L.R. Rubenstein,Michael S. German +6 more
TL;DR: It is proposed that Nkx2.2 is required for the final differentiation of pancreatic beta cells, and in its absence, beta cells are trapped in an incompletely differentiated state.
Journal ArticleDOI
Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade
Ziming Wang,Ethan G. Aguilar,Jesus I. Luna,Cordelia Dunai,Lam T. Khuat,Catherine T. Le,Annie Mirsoian,Christine M. Minnar,Kevin Stoffel,Ian R. Sturgill,Steven K. Grossenbacher,Sita S. Withers,Robert B. Rebhun,Dennis J. Hartigan-O'Connor,Gema Méndez-Lagares,Alice F. Tarantal,Roslyn Rivkah Isseroff,Roslyn Rivkah Isseroff,Thomas S. Griffith,Kurt A. Schalper,Alexander A. Merleev,Asim Saha,Emanual Michael Maverakis,Karen Kelly,Raid Aljumaily,Sami Ibrahimi,Sarbajit Mukherjee,Michael Machiorlatti,Sara K. Vesely,Dan L. Longo,Bruce R. Blazar,Robert J. Canter,William J. Murphy,Arta M. Monjazeb +33 more
TL;DR: It is demonstrated, across multiple species and tumor models, that obesity results in increased immune aging, tumor progression and PD-1-mediated T cell dysfunction which is driven, at least in part, by leptin.
Journal ArticleDOI
Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells.
TL;DR: This work analyzed the expression of fourteen intracellular and cell surface markers on human CD4(+) cells to identify markers that are sensitive and specific for human T-regs, and found a surface phenotype that should allow for quantitative studies of Regulatory T cells in disease states as well as for enrichment of live regulatory T cells for functional analyses and/or expansion in vitro.
Journal ArticleDOI
Functional correction of adult mdx mouse muscle using gutted adenoviral vectors expressing full-length dystrophin
Christiana DelloRusso,Jeannine M. Scott,Dennis J. Hartigan-O'Connor,Dennis J. Hartigan-O'Connor,Giovanni Salvatori,Catherine Barjot,Catherine Barjot,Ann S. Robinson,Ann S. Robinson,Robert W. Crawford,Susan V. Brooks,Jeffrey S. Chamberlain,Jeffrey S. Chamberlain +12 more
TL;DR: It is shown that high titer stocks of three different gutted adenoviral vectors carrying full-length, muscle-specific, dystrophin expression cassettes are able to efficiently transduce muscles of 1-yr-old mdx mice, raising the prospects for gene therapy of muscular Dystrophies.