M
Michael S. German
Researcher at University of California, San Francisco
Publications - 144
Citations - 14515
Michael S. German is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Cellular differentiation & Insulin. The author has an hindex of 64, co-authored 141 publications receiving 13631 citations. Previous affiliations of Michael S. German include California Institute for Regenerative Medicine & Rockefeller University.
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Journal ArticleDOI
Expression of neurogenin3 reveals an islet cell precursor population in the pancreas.
Valerie M. Schwitzgebel,David W. Scheel,Jennifer R. Conners,J. Kalamaras,Jacqueline E. Lee,David Anderson,Lori Sussel,Jeffrey D. Johnson,Michael S. German +8 more
TL;DR: The ability to uniquely identify islet cell precursors by neurogenin3 expression allows us to determine the position of other islet transcription factors in the differentiation cascade and to propose a map for the is let cell differentiation pathway.
Journal ArticleDOI
Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells
Lori Sussel,J. Kalamaras,Dennis J. Hartigan-O'Connor,Juanito J. Meneses,Roger A. Pedersen,John L.R. Rubenstein,Michael S. German +6 more
TL;DR: It is proposed that Nkx2.2 is required for the final differentiation of pancreatic beta cells, and in its absence, beta cells are trapped in an incompletely differentiated state.
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Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development.
TL;DR: Genetic and biochemical evidence is presented that Pax6 is a key regulator of pancreatic islet hormone gene transcription and is required for normal islet development and that PAX6 transactivates the glucagon and insulin promoters.
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Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas.
Maike Sander,Lori Sussel,Jennifer R. Conners,David W. Scheel,J. Kalamaras,F. Dela Cruz,Valerie M. Schwitzgebel,A. Hayes-Jordan,Michael S. German +8 more
TL;DR: Together, these experiments reveal two independently controlled pathways for beta-cell differentiation, and place Nkx6.1 downstream of NKx2.2 in the major pathway of beta- cell differentiation.
Journal ArticleDOI
Serotonin regulates pancreatic beta cell mass during pregnancy.
Hail Kim,Yukiko Toyofuku,Francis C. Lynn,Francis C. Lynn,Eric W Chak,Toyoyoshi Uchida,Hiroki Mizukami,Yoshio Fujitani,Ryuzo Kawamori,Takeshi Miyatsuka,Yasuhiro Kosaka,Katherine Yang,Gerard Honig,Marieke van der Hart,Nina Kishimoto,Juehu Wang,Soroku Yagihashi,Laurence H. Tecott,Hirotaka Watada,Michael S. German +19 more
TL;DR: An integrated signaling pathway linking beta cell mass to anticipated insulin need during pregnancy is revealed and modulators of this pathway, including medications and diet, may affect the risk of gestational diabetes.