J
Julie A. Hutt
Researcher at Lovelace Respiratory Research Institute
Publications - 48
Citations - 2399
Julie A. Hutt is an academic researcher from Lovelace Respiratory Research Institute. The author has contributed to research in topics: Lung cancer & Bacillus anthracis. The author has an hindex of 24, co-authored 47 publications receiving 2195 citations. Previous affiliations of Julie A. Hutt include University of New Mexico.
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Journal ArticleDOI
Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation
Eliseo F. Castillo,Alexander Dekonenko,John Arko-Mensah,Michael A. Mandell,Nicolas Dupont,Shanya Jiang,Monica Delgado-Vargas,Graham S. Timmins,Dhruva Bhattacharya,Hongliang Yang,Julie A. Hutt,C. Rick Lyons,Karen M. Dobos,Vojo Deretic +13 more
TL;DR: It is shown that autophagy plays a dual role against tuberculosis: antibacterial and anti-inflammatory, suppressing both M. tuberculosis growth and damaging inflammation.
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Capsule synthesis by Bacillus anthracis is required for dissemination in murine inhalation anthrax
TL;DR: It is shown that a strain carrying both virulence plasmids but deleted specifically for capBCAD is highly attenuated in a mouse model for inhalation anthrax, indicating that acpA and acpB are not true functional homologs and that acPB may play a larger role in virulence than originally suspected.
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Murine model of pulmonary anthrax: kinetics of dissemination, histopathology, and mouse strain susceptibility.
C. Rick Lyons,Julie A. Lovchik,Julie A. Hutt,Mary F. Lipscomb,Eugenia Wang,Sara Heninger,Lucy Berliba,Kristin Garrison +7 more
TL;DR: The characteristics of host and Bacillus anthracis interactions in a murine pulmonary-infection model are described to investigate the importance of specific bacterial genes in virulence, to identify components of the host immune system that are important in providing innate and acquired protection, and for testing diagnostic and therapeutic strategies.
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Intranasal vaccination induces protective immunity against intranasal infection with virulent Francisella tularensis biovar A.
Terry H. Wu,Julie A. Hutt,Julie A. Hutt,Kristin Garrison,Lyudmila S. Berliba,Yan Zhou,C. Rick Lyons +6 more
TL;DR: These results show that intranasal vaccination induces immunity that protects BALB/c mice from intranAsal infection by F. tularensis biovar A and required both CD4 and CD8 T cells.
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Aberrant Promoter Hypermethylation of the Death-Associated Protein Kinase Gene Is Early and Frequent in Murine Lung Tumors Induced by Cigarette Smoke and Tobacco Carcinogens
TL;DR: This study is the first to use a murine model of cigarette smoke-induced lung cancer and demonstrate commonality for inactivation by promoter hypermethylation of a gene implicated in the development of this disease in humans.