T
Theodora R. Devereux
Researcher at National Institutes of Health
Publications - 108
Citations - 4835
Theodora R. Devereux is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Carcinogenesis & Mutation. The author has an hindex of 42, co-authored 108 publications receiving 4773 citations. Previous affiliations of Theodora R. Devereux include Research Triangle Park.
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Journal ArticleDOI
Wildtype Kras2 can inhibit lung carcinogenesis in mice.
Zhongqiu Zhang,Yian Wang,Haris G. Vikis,Leisa Johnson,Gongjie Liu,Jie Li,Marshall W. Anderson,Robert C. Sills,Hue-Hua L. Hong,Theodora R. Devereux,Tyler Jacks,Kun-Liang Guan,Ming You +12 more
TL;DR: Data suggest that wildtype Kras2 has tumor suppressor activity and is frequently lost during lung tumor progression, as well as an inverse correlation between the level of wildtypes expression and extracellular signal–regulated kinase (ERK) activity in these cells.
Journal Article
DNA methylation analysis of the promoter region of the human telomerase reverse transcriptase (hTERT) gene.
Theodora R. Devereux,Izumi Horikawa,Colleen H. Anna,Lois A. Annab,Cynthia A. Afshari,J C Barrett +5 more
TL;DR: There are multiple levels of regulation of hTERT expression in CpG island methylation-dependent and -independent manners, indicating a potential role for DNA methylation and/or histone deacetylation in negative regulation ofhTERT.
Journal Article
Relationship between the Formation of Promutagenic Adducts and the Activation of the K-ras Protooncogene in Lung Tumors from A/J Mice Treated with Nitrosamines
Steven A. Belinsky,Theodora R. Devereux,Robert R. Maronpot,Gary D. Stoner,Marshall W. Anderson +4 more
TL;DR: Southern blot analysis indicated that the transforming gene present in all lung tumors was an activated K-ras oncogene, and this gene appeared to occur largely via a mutation in codon 12 and was observed with a similar frequency in pulmonary tumors induced by either NNK or NDMA.
Journal Article
Role of the alveolar type II cell in the development and progression of pulmonary tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the A/J mouse.
Steven A. Belinsky,Theodora R. Devereux,Julie F. Foley,Robert R. Maronpot,Marshall W. Anderson +4 more
TL;DR: The role of the type II cell in the development of pulmonary tumors induced in the adult A/J mouse (6 weeks of age) by treatment with a single dose (100 mg/kg, i.p.) of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) was investigated as mentioned in this paper.
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Mutation of β-catenin is an early event in chemically induced mouse hepatocellular carcinogenesis
TL;DR: There appears to be a chemical specific involvement of β-catenin activation in mouse hepatocellular carcinogenesis, and expression analyses using Western blot and immunohistochemistry indicate that β-Catenin protein accumulates along cell membranes following mutation.