J
Julie Klein
Researcher at University of Toulouse
Publications - 72
Citations - 2222
Julie Klein is an academic researcher from University of Toulouse. The author has contributed to research in topics: Kidney disease & Kidney. The author has an hindex of 24, co-authored 68 publications receiving 1875 citations. Previous affiliations of Julie Klein include French Institute of Health and Medical Research & University of Manchester.
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Journal ArticleDOI
LPA1 Receptor Activation Promotes Renal Interstitial Fibrosis
Jean-Philippe Pradere,Julie Klein,Sandra Grès,Charlotte Guigné,Eric Neau,Philippe Valet,Denis Calise,Jerold Chun,Jean-Loup Bascands,Jean-Sébastien Saulnier-Blache,Joost P. Schanstra +10 more
TL;DR: LPA, likely acting through LPA1, is involved in obstruction-induced TIF, and the LPA2 or LPA4 receptor might be a pharmaceutical target to treat renal fibrosis.
Journal ArticleDOI
Lysophosphatidic acid and renal fibrosis.
Jean-Philippe Pradere,Julien Gonzalez,Julien Gonzalez,Julie Klein,Julie Klein,Philippe Valet,Philippe Valet,Sandra Grès,Sandra Grès,David J. Salant,Jean-Loup Bascands,Jean-Loup Bascands,Jean-Sébastien Saulnier-Blache,Jean-Sébastien Saulnier-Blache,Joost P. Schanstra,Joost P. Schanstra +15 more
TL;DR: LPA1-receptor activation was found to be associated with increased vascular leakage and increased fibroblast recruitment in pulmonary fibrosis and in renal fibrosis, making this receptor an interesting alternative and new therapeutic target in fibrotic diseases.
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Proteasix: A tool for automated and large-scale prediction of proteases involved in naturally occurring peptide generation
TL;DR: Proteasix, an open‐source peptide‐centric tool that can be used to predict in silico the proteases involved in naturally occurring peptide generation, is developed, which allows CS retrieval and protease associations from a list of peptides.
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Assessment of Metabolomic and Proteomic Biomarkers in Detection and Prognosis of Progression of Renal Function in Chronic Kidney Disease
Esther Nkuipou-Kenfack,Flore Duranton,Nathalie Gayrard,Àngel Argilés,Ulrika Lundin,Klaus M. Weinberger,Mohammed Dakna,Christian Delles,William Mullen,Holger Husi,Julie Klein,Thomas Koeck,Petra Zürbig,Harald Mischak +13 more
TL;DR: Excellent association of plasma and urinary metabolites and urinary peptides with kidney function, and disease progression, but no added value in combining the different biomarkers data is found.
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Comparison of CE-MS/MS and LC-MS/MS sequencing demonstrates significant complementarity in natural peptide identification in human urine.
TL;DR: It was showed that LC‐ MS/MS and CE‐MS/MS are highly complementary in identifying peptide sequences, and the combination of both technologies results in significantly increased sequence coverage.