J
Joost P. Schanstra
Researcher at University of Toulouse
Publications - 100
Citations - 4035
Joost P. Schanstra is an academic researcher from University of Toulouse. The author has contributed to research in topics: Kidney disease & Kidney. The author has an hindex of 32, co-authored 100 publications receiving 3459 citations. Previous affiliations of Joost P. Schanstra include French Institute of Health and Medical Research & RWTH Aachen University.
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Journal ArticleDOI
Urine in Clinical Proteomics
Stéphane Decramer,Stéphane Decramer,Anne Gonzalez de Peredo,Benjamin Breuil,Benjamin Breuil,Harald Mischak,Bernard Monsarrat,Jean-Loup Bascands,Jean-Loup Bascands,Joost P. Schanstra,Joost P. Schanstra +10 more
TL;DR: Urine has evolved as one of the most attractive body fluids in clinical proteomics with potentially a rapid application in the clinic with potentially an era of validation of urinary biomarkers in larger prospective studies.
Journal ArticleDOI
Predicting the clinical outcome of congenital unilateral ureteropelvic junction obstruction in newborn by urinary proteome analysis
Stéphane Decramer,Stefan Wittke,Harald Mischak,Petra Zürbig,Michael Walden,François Bouissou,François Bouissou,Jean-Loup Bascands,Jean-Loup Bascands,Joost P. Schanstra,Joost P. Schanstra +10 more
TL;DR: Using urinary polypeptides from individuals with neonatal ureteropelvic junction obstruction, this work was able to predict, several months in advance and with 94% precision, the clinical evolution of neonates with UPJ obstruction.
Journal ArticleDOI
CE-MS analysis of the human urinary proteome for biomarker discovery and disease diagnostics
Joshua J. Coon,Petra Zürbig,Mohammed Dakna,Anna F. Dominiczak,Stéphane Decramer,Stéphane Decramer,Danilo Fliser,Moritz Frommberger,Igor Golovko,David M. Good,Stefan Herget-Rosenthal,Joachim Jankowski,Bruce A. Julian,Markus Kellmann,Walter Kolch,Ziad A. Massy,Jan Novak,Kasper Rossing,Joost P. Schanstra,Joost P. Schanstra,Eric Schiffer,Dan Theodorescu,Raymond Vanholder,Eva M. Weissinger,Harald Mischak,Philippe Schmitt-Kopplin +25 more
TL;DR: CE‐MS, which was used to analyze urine samples from healthy subjects and patients with various diseases, is a suitable approach for this task and exhibits excellent performance for biomarker discovery and allows subsequent biomarker sequencing independent of the separation platform.
Journal ArticleDOI
Capillary electrophoresis–mass spectrometry as a powerful tool in biomarker discovery and clinical diagnosis: an update of recent developments
Harald Mischak,Joshua J. Coon,Jan Novak,Eva M. Weissinger,Joost P. Schanstra,Joost P. Schanstra,Anna F. Dominiczak +6 more
TL;DR: This review examines the limitations of proteomics, and aims towards the definition of the current key prerequisites for biomarker discovery and clinical applications, focusing on capillary electrophoresis coupled to mass spectrometry (CE-MS).
Journal ArticleDOI
Addressing the Challenge of Defining Valid Proteomic Biomarkers and Classifiers
Mohammed Dakna,Keith Harris,Alexandros Kalousis,Sebastien Carpentier,Walter Kolch,Joost P. Schanstra,Joost P. Schanstra,Marion Haubitz,Antonia Vlahou,Harald Mischak,Mark Girolami +10 more
TL;DR: Valid proteomic biomarkers for diagnosis and prognosis only can be defined by applying proper statistical data mining procedures, and a justification of the sample size should be part of the study design.