J
Julie L. Wilsbacher
Researcher at University of Texas Southwestern Medical Center
Publications - 22
Citations - 3019
Julie L. Wilsbacher is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Mitogen-activated protein kinase kinase & Phosphorylation. The author has an hindex of 19, co-authored 22 publications receiving 2911 citations. Previous affiliations of Julie L. Wilsbacher include Harvard University & Merck KGaA.
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Journal ArticleDOI
Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation.
Andrei Khokhlatchev,Bertram Canagarajah,Julie L. Wilsbacher,Megan Robinson,Mark A. L. Atkinson,Elizabeth J. Goldsmith,Melanie H. Cobb +6 more
TL;DR: The MAP kinase ERK2 is widely involved in eukaryotic signal transduction and upon activation it translocates to the nucleus of the stimulated cell, where it phosphorylates nuclear targets and forms dimers.
Journal ArticleDOI
WNK1, a Novel Mammalian Serine/Threonine Protein Kinase Lacking the Catalytic Lysine in Subdomain II
Bing E. Xu,Jessie M. English,Jessie M. English,Julie L. Wilsbacher,Julie L. Wilsbacher,Steve Stippec,Elizabeth J. Goldsmith,Melanie H. Cobb +7 more
TL;DR: Mutation of this lysine residue to methionine eliminates WNK1 activity, consistent with the conclusion that it is required for catalysis, and indicates that W NK1 belongs to a novel family of serine/threonine protein kinases.
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New Insights into the Control of MAP Kinase Pathways
Jessie M. English,Gray W. Pearson,Julie L. Wilsbacher,Jennifer L. Swantek,Mahesh Karandikar,Shuichan Xu,Melanie H. Cobb +6 more
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Vav GEFs are required for β2 integrin-dependent functions of neutrophils
M. Angelica Martinez Gakidis,Xavier Cullere,Timothy S. Olson,Julie L. Wilsbacher,Bin Zhang,Sheri L. Moores,Klaus Ley,Wojciech Swat,Tanya N. Mayadas,Joan S. Brugge +9 more
TL;DR: It is shown that Vav proteins are required for multiple β2 integrin-dependent functions, including sustained adhesion, spreading, and complement-mediated phagocytosis in Vav1/Vav3-deficient neutrophils.
Journal ArticleDOI
Requirements for Vav Guanine Nucleotide Exchange Factors and Rho GTPases in FcγR- and Complement-Mediated Phagocytosis
Amy B. Hall,M. Angelica Martinez Gakidis,Michael Glogauer,Julie L. Wilsbacher,Sizhen Gao,Wojciech Swat,Joan S. Brugge +6 more
TL;DR: Analysis of primary murine macrophages shows that constitutively active Rac is able to rescue actin polymerization and complement-mediated phagocytosis in Vav-deficient macrophage, suggesting that Rac is regulated by GEFs other than Vav downstream of the FcgammaR.