J
Julie Miller
Researcher at Salisbury University
Publications - 39
Citations - 1421
Julie Miller is an academic researcher from Salisbury University. The author has contributed to research in topics: Antigen & Immunogenicity. The author has an hindex of 21, co-authored 39 publications receiving 1380 citations. Previous affiliations of Julie Miller include University of London & Defence Evaluation and Research Agency.
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Journal ArticleDOI
Human immune response to a plague vaccine comprising recombinant F1 and V antigens
E. D. Williamson,Helen C. Flick-Smith,Chris S. LeButt,Caroline A. Rowland,Steven M. Jones,E. L. Waters,R. J. Gwyther,Julie Miller,P. J. Packer,M. Irving +9 more
TL;DR: The human immune response to a new recombinant plague vaccine, comprising recombinant F1 (rF1) and rV antigens, has been assessed during a phase 1 safety and immunogenicity trial in healthy volunteers, and potential serological immune correlates of protection have been investigated.
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A recombinant carboxy-terminal domain of the protective antigen of Bacillus anthracis protects mice against anthrax infection.
Helen C. Flick-Smith,Nicola J. Walker,Paula Gibson,Helen L. Bullifent,Sarah Hayward,Julie Miller,Richard W. Titball,E. Diane Williamson +7 more
TL;DR: Results show that protection can be attributed to individual domains and imply that it is domain 4 which contains the dominant protective epitopes of PA.
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Mucosal or parenteral administration of microsphere-associated Bacillus anthracis protective antigen protects against anthrax infection in mice.
Helen C. Flick-Smith,Jim E. Eyles,Richard Hebdon,Emma L. Waters,R. J. Beedham,Tony J. Stagg,Julie Miller,H. Oya Alpar,Les Baillie,E. Diane Williamson +9 more
TL;DR: Results show that rPA can be encapsulated and surface bound to polymeric microspheres without impairing its immunogenicity and also that mucosal or parenteral administration of microspheric formulations of rPA efficiently protects mice against both injected and aerosol challenges with B. anthracis spores.
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Protective efficacy of a recombinant protective antigen against Bacillus anthracis challenge and assessment of immunological markers
TL;DR: In this paper, the efficacy of recombinant Bacillus anthracis Protective Antigen (rPA) produced in Bacillus subtilis and formulated in Alhydrogel or MPL-TDM-CWS (Ribi adjuvant) has been tested and compared to the licensed UK human vaccine in guinea pigs challenged by the aerosol route with the Ames strain of B. anthrasis.
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Probing Molecular Interactions in Intact Antibody: Antigen Complexes, an Electrospray Time-of-Flight Mass Spectrometry Approach
Mark A. Tito,Julie Miller,Nicola J. Walker,Kate F. Griffin,E. Diane Williamson,Dominique Despeyroux-Hill,Richard W. Titball,Carol V. Robinson +7 more
TL;DR: Using a combination of nanoflow-electrospray ionization and time-of-flight mass spectrometry, this work demonstrates a rapid means of assessing antigen subunit interactions as well as the stoichiometry and specificity of binding in antibody-antigen complexes.